ArticlePLoS biology2011
Sucrose utilization in budding yeast as a model for the origin of undifferentiated multicellularity.
Article in PLoS biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 119 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
119 citing papers in PubMed.
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- Influence of cell-cell distance on the ecology and evolution of microbial communities.The ISME journal · 2026Review
- Natural Allelic Variations in IbCHYR1-IbZnFR Complex Regulate Fusarium Root Rot Resistance in Sweet Potato.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Assessment of the antifungal activity of Actinidia deliciosa derived exosome like nanoparticles.Scientific reports · 2025Article
- Partner dependency alters patterns of coevolutionary selection in mutualisms.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling.Cell stem cell · 2025Article
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- Conserved signaling modules regulate filamentous growth in fungi: a model for eukaryotic cell differentiation.Genetics · 2024Review
- A dynamic network model predicts the phenotypes of multicellular clusters from cellular properties.Current biology : CB · 2024Article
- Tannin-TolerantFoods (Basel, Switzerland) · 2024Article
- Increased privatization of a public resource leads to spread of cooperation in a microbial population.Microbiology spectrum · 2024Article
- Optogenetic spatial patterning of cooperation in yeast populations.Nature communications · 2024Article
- Multicellular growth as a dynamic network of cells.bioRxiv : the preprint server for biology · 2023Article
- Bacterial bioconvection confers context-dependent growth benefits and is robust under varying metabolic and genetic conditions.Journal of bacteriology · 2023Article
- Multicellularity and the Need for Communication-A Systematic Overview on (Algal) Plasmodesmata and Other Types of Symplasmic Cell Connections.Plants (Basel, Switzerland) · 2023Review
- Bacteria evolve macroscopic multicellularity by the genetic assimilation of phenotypically plastic cell clustering.Nature communications · 2023Article
- Single-cell adaptations shape evolutionary transitions to multicellularity in green algae.Nature ecology & evolution · 2023Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedKoschwanez, John H [corrected to Koschwanez, J H]; Foster, Kevin R [corrected to Foster, K R]; Murray, Andrew W [corrected to Murray, A W].
Authors and funding
3 authors.
Funding
Abstract
We use the budding yeast, Saccharomyces cerevisiae, to investigate one model for the initial emergence of multicellularity: the formation of multicellular aggregates as a result of incomplete cell separation. We combine simulations with experiments to show how the use of secreted public goods favors the formation of multicellular aggregates. Yeast cells can cooperate by secreting invertase, an enzyme that digests sucrose into monosaccharides, and many wild isolates are multicellular because cell walls remain attached to each other after the cells divide. We manipulate invertase secretion and cell attachment, and show that multicellular clumps have two advantages over single cells: they grow under conditions where single cells cannot and they compete better against cheaters, cells that do not make invertase. We propose that the prior use of public goods led to selection for the incomplete cell separation that first produced multicellularity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.