ArticleNeuropsychiatric disease and treatment2011
APRESS: apical regulatory super system, serotonin, and dopamine interaction.
Article in Neuropsychiatric disease and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Parkinson's disease managing reversible neurodegeneration.Neuropsychiatric disease and treatment · 2016Article
- The vesicle-associated function of NOD2 as a link between Crohn's disease and mycobacterial infection.Gut pathogens · 2015Article
- Administration of supplemental L-tyrosine with phenelzine: a clinical literature review.Clinical pharmacology : advances and applications · 2014Review
- Management of L-dopa overdose in the competitive inhibition state.Drug, healthcare and patient safety · 2014Article
- The Parkinson's disease death rate: carbidopa and vitamin B6.Clinical pharmacology : advances and applications · 2014Article
- Parkinson's disease: carbidopa, nausea, and dyskinesia.Clinical pharmacology : advances and applications · 2014Article
- Parkinson's disease-associated melanin steal.Neuropsychiatric disease and treatment · 2014Article
- 5-HTP efficacy and contraindications.Neuropsychiatric disease and treatment · 2012Article
- Relative nutritional deficiencies associated with centrally acting monoamines.International journal of general medicine · 2012Article
- The discrediting of the monoamine hypothesis.International journal of general medicine · 2012Article
- Monoamine depletion by reuptake inhibitors.Drug, healthcare and patient safety · 2011Article
Corrections and comments
- Retraction · 2020-12-16Concerns/Issues about Data · Ethical Violations by Author · Informed/Patient Consent - None/Withdrawn · Investigation by Journal/Publisher · Lack of IRB/IACUC Approval and/or Compliance · Upgrade/Update of Prior Notice(s) ·
- Expression of concern · 2020-04-23Concerns/Issues about Data · Conflict of Interest · Investigation by Journal/Publisher · Updated to Retraction ·
- Expression of concern
- Retracted
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTHE MONOAMINES SEROTONIN AND DOPAMINE ARE KNOWN TO EXIST IN TWO SEPARATE STATES: the endogenous state and the competitive inhibition state. The presence of the competitive inhibition state has been known to science for many years, but from a functional standpoint it has been noted in the literature as being "meaningless."
methodsA large database of monoamine transporter response to amino acid precursor administration variations with clinical outcomes was accumulated. In the process, a new organic cation transporter (OCT) model has been published, and OCT functional status determination along with amino acid precursor manipulation methods have been invented and refined.
resultsMethodology was developed whereby manipulation of the OCT, in the competitive inhibition state, is carried out in a predictable manner. This, in turn, has disproved the long-held assertion that the monoamine competitive inhibition state is functionally meaningless.
conclusionThe most significant aspect of this paper is the documentation of newly recognized relationships between serotonin and dopamine. When transport of serotonin and dopamine are both in the competitive inhibition state, manipulation of the concentrations of one will lead to predictable changes in concentrations of the other. From a functional standpoint, processes regulated and controlled by changes to only serotonin can now be controlled by changes to dopamine, and vice versa, in a predictable manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.