ArticleNeuropsychiatric disease and treatment2011
Ginkgo biloba extract in the treatment of tinnitus: a systematic review.
Article in Neuropsychiatric disease and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 6 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Ginkgo biloba for tinnitus.The Cochrane database of systematic reviews · 2022Pooled it
- Guideline
- A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment.HNO · 2019Guideline
- Pooled it
- A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Tinnitus.BMJ clinical evidence · 2014Pooled it
- Ginkgo biloba extract EGb 761International journal of clinical pharmacy · 2018Trial
- Antioxidant therapy in the elderly with tinnitus.Brazilian journal of otorhinolaryngologyTrial
- Benefits of a Natural Dietary Supplement for Tinnitus: An Observational Prospective Exploratory Study.Audiology research · 2026Article
- Article
- Does the Patient's Sex Have an Impact on Beneficial Effects ofJournal of clinical medicine · 2025Article
- Real-World Multicenter Evaluation of MEMOTIN® for Tinnitus in Private Clinic Settings: The M.E.S.T Study.Cureus · 2025Article
- Proanthocyanidins from Ginkgo extract EGb 761Frontiers in pharmacology · 2025Article
- Proanthocyanidins fromFrontiers in pharmacology · 2025Article
- Alarming Signal from the Ear: Tinnitus, a Possible Epiphenomenon of Silent Hyperlipidaemia.Biomedicines · 2024Article
- Substantial Differences in Proanthocyanidin Contents among Ginkgo biloba Leaf Extracts in Herbal Medicinal Products Obtained from the German Market.Planta medica · 2024Article
- Combination Therapy of Choline Alfoscerate With Ginkgo biloba Monotherapy in Age-Related Hearing Loss: Effects and Outcomes.Journal of audiology & otology · 2024Article
- The effect of MemoVigor 2 on recent-onset idiopathic tinnitus: a randomized double-blind placebo-controlled clinical trial.Frontiers in pharmacology · 2024Article
- Article
- Efficacy and Safety of Co-Administered St. John's Wort andJournal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus is a symptom frequently encountered by ear, nose, and throat practitioners. A causal treatment is rarely possible, and drug and nondrug treatment options are limited. One of the frequently prescribed treatments is Ginkgo biloba extract. Therefore, randomized, placebo-controlled clinical trials of Ginkgo biloba extract preparations were searched for and reviewed systematically. There is evidence of efficacy for the standardized extract, EGb 761(®) (Dr Willmar Schwabe GmbH & Co KG Pharmaceuticals, Karlsruhe, Germany), in the treatment of tinnitus from three trials in patients in whom tinnitus was the primary complaint. Supportive evidence comes from a further five trials in patients with age-associated cognitive impairment or dementia in whom tinnitus was present as a concomitant symptom. As yet, the efficacy of other ginkgo preparations has not been proven, which does not necessarily indicate ineffectiveness, but may be due to flawed clinical trials. In conclusion, EGb 761(®), a standardized Ginkgo biloba extract, is an evidence-based treatment option in tinnitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.