ArticleJournal of micromechanics and microengineering : structures, devices, and systems2011
Integrated strain array for cellular mechanobiology studies.
Article in Journal of micromechanics and microengineering : structures, devices, and systems, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- Development of a Pneumatic-Driven Fiber-Shaped Robot Scaffold for Use as a Complex 3D Dynamic Culture System.Biomimetics (Basel, Switzerland) · 2023Article
- An Easy-to-Fabricate Cell Stretcher Reveals Density-Dependent Mechanical Regulation of Collective Cell Movements in Epithelia.Cellular and molecular bioengineering · 2021Article
- In-Line Analysis of Organ-on-Chip Systems with Sensors: Integration, Fabrication, Challenges, and Potential.ACS biomaterials science & engineering · 2021Article
- Article
- A high throughput screening system for studying the effects of applied mechanical forces on reprogramming factor expression.Scientific reports · 2020Article
- Label-free cell sorting strategies via biophysical and biochemical gradients.Journal of orthopaedic translation · 2019Review
- Article
- An ultra-fast mechanically active cell culture substrate.Scientific reports · 2018Article
- Incorporating mechanical strain in organs-on-a-chip: Lung and skin.Biomicrofluidics · 2018Article
- Adhesion to the host cell surface is sufficient to mediateMolecular biology of the cell · 2017Article
- E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Endothelial cell alignment as a result of anisotropic strain and flow induced shear stress combinations.Scientific reports · 2016Article
- Concurrent shear stress and chemical stimulation of mechano-sensitive cells by discontinuous dielectrophoresis.Biomicrofluidics · 2016Article
- For whom the cells pull: Hydrogel and micropost devices for measuring traction forces.Methods (San Diego, Calif.) · 2016Review
- Analysing calcium signalling of cells under high shear flows using discontinuous dielectrophoresis.Scientific reports · 2015Article
- Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry.Science (New York, N.Y.) · 2015Article
- Computational analysis of fluid flow within a device for applying biaxial strain to cultured cells.Journal of biomechanical engineering · 2015Article
- The mechanobiology of brain function.Nature reviews. Neuroscience · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
We have developed an integrated strain array for cell culture enabling high-throughput mechano-transduction studies. Biocompatible cell culture chambers were integrated with an acrylic pneumatic compartment and microprocessor-based control system. Each element of the array consists of a deformable membrane supported by a cylindrical pillar within a well. For user-prescribed waveforms, the annular region of the deformable membrane is pulled into the well around the pillar under vacuum, causing the pillar-supported region with cultured cells to be stretched biaxially. The optically clear device and pillar-based mechanism of operation enables imaging on standard laboratory microscopes. Straightforward fabrication utilizes off-the-shelf components, soft lithography techniques in polydimethylsiloxane, and laser ablation of acrylic sheets. Proof of compatibility with basic biological assays and standard imaging equipment were accomplished by straining C2C12 skeletal myoblast cells on the device for 6 hours. At higher strains, cells and actin stress fibers realign with a circumferential preference.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.