ArticleNature materials2011
In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging.
Article in Nature materials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed.
- Material Composition and Implantation Site Affect in vivo Device Degradation Rate.Research square · 2026Article
- From passive sealing to active microenvironment remodeling: design strategies, biological effects, and translational challenges of multifunctional hydrogels for postoperative pancreatic fistula prevention.Frontiers in bioengineering and biotechnology · 2026Review
- Transforming Cancer Diagnosis and Therapy Through Fluorescent Hydrogels: A Review.Advanced healthcare materials · 2026Review
- A novel inherent fluorescence biodegradable polyurethane.Regenerative biomaterials · 2026Article
- Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro-Inflammatory Macrophage Activation.Advanced healthcare materials · 2025Article
- Sporopollenin-based material for prevention of postoperative adhesions: a murine study.Annals of surgical treatment and research · 2025Article
- Leveraging printability and biocompatibility in materials for printing implantable vessel scaffolds.Materials today. Bio · 2024Review
- Multi-Functional Biomaterial for the Treatment and Prevention of Central Line-Associated Bloodstream Infections.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Dual-Self-Crosslinking Effect of Alginate-Di-Aldehyde with Natural and Synthetic Co-Polymers as Injectable In Situ-Forming Biodegradable Hydrogel.Gels (Basel, Switzerland) · 2024Article
- Material Composition and Implantation Site Affect in vivo Device Degradation Rate.bioRxiv : the preprint server for biology · 2024Article
- Article
- Multi-modal imaging for dynamic visualization of osteogenesis and implant degradation in 3D bioprinted scaffolds.Bioactive materials · 2024Article
- Dynamic monitoring soft tissue healing via visualized Gd-crosslinked double network MRI microspheres.Journal of nanobiotechnology · 2024Article
- A Single-Shot Scattering Medium Imaging Method via Bispectrum Truncation.Sensors (Basel, Switzerland) · 2024Article
- Degradation Kinetics of Disulfide Cross-Linked Microgels: Real-Time Monitoring by Confocal Microscopy.Gels (Basel, Switzerland) · 2023Article
- Mass Spectrometry Imaging of Biomaterials.Materials (Basel, Switzerland) · 2023Review
- Fluorescent-Nanoparticle-Impregnated Nanocomposite Polymeric Gels for Biosensing and Drug Delivery Applications.Gels (Basel, Switzerland) · 2023Review
- Methacrylate-Modified Gold Nanoparticles Enable Non-Invasive Monitoring of Photocrosslinked Hydrogel Scaffolds.Advanced nanobiomed research · 2022Article
- Large field-of-view non-invasive imaging through scattering layers using fluctuating random illumination.Nature communications · 2022Article
- An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing.Bioactive materials · 2021Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
The design of erodible biomaterials relies on the ability to program the in vivo retention time, which necessitates real-time monitoring of erosion. However, in vivo performance cannot always be predicted by traditional determination of in vitro erosion, and standard methods sacrifice samples or animals, preventing sequential measures of the same specimen. We harnessed non-invasive fluorescence imaging to sequentially follow in vivo material-mass loss to model the degradation of materials hydrolytically (PEG:dextran hydrogel) and enzymatically (collagen). Hydrogel erosion rates in vivo and in vitro correlated, enabling the prediction of in vivo erosion of new material formulations from in vitro data. Collagen in vivo erosion was used to infer physiologic in vitro conditions that mimic erosive in vivo environments. This approach enables rapid in vitro screening of materials, and can be extended to simultaneously determine drug release and material erosion from a drug-eluting scaffold, or cell viability and material fate in tissue-engineering formulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.