ArticleNature cell biology2011
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.
Article in Nature cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 71 citations in OpenAlex.
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- Transcriptional regulation of the piRNA pathway by Ovo in animal ovarian germ cells.Genes & development · 2025Article
- Notch Signaling in Drosophila Tumor Models.Advances in experimental medicine and biology · 2025Review
- Unveiling the Tumor Suppressors: Insights from Drosophila.Advances in experimental medicine and biology · 2025Review
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- Lint-O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brain.EMBO reports · 2022Article
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- A continuation method for spatially discretized models with nonlocal interactions conserving size and shape of cells and lattices.Journal of mathematical biology · 2020Article
- Distinct CoREST complexes act in a cell-type-specific manner.Nucleic acids research · 2019Article
- The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy inScience advances · 2019Article
- The same domain of Su(Hw) is required for enhancer blocking and direct promoter repression.Scientific reports · 2019Article
- A newly discovered neural stem cell population is generated by the optic lobe neuroepithelium during embryogenesis inDevelopment (Cambridge, England) · 2018Article
- L(3)mbt and the LINT complex safeguard cellular identity in theDevelopment (Cambridge, England) · 2018Article
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- RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.The EMBO journal · 2017Article
- AnOpen biology · 2017Article
- Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours inBioMed research international · 2017Article
- Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.Genes & development · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
In Drosophila, defects in asymmetric cell division often result in the formation of stem-cell-derived tumours. Here, we show that very similar terminal brain tumour phenotypes arise through a fundamentally different mechanism. We demonstrate that brain tumours in l(3)mbt mutants originate from overproliferation of neuroepithelial cells in the optic lobes caused by derepression of target genes in the Salvador-Warts-Hippo (SWH) pathway. We use ChIP-sequencing to identify L(3)mbt binding sites and show that L(3)mbt binds to chromatin insulator elements. Mutating l(3)mbt or inhibiting expression of the insulator protein gene mod(mdg4) results in upregulation of SWH pathway reporters. As l(3)mbt tumours are rescued by mutations in bantam or yorkie or by overexpression of Expanded, the deregulation of SWH pathway target genes is an essential step in brain tumour formation. Therefore, very different primary defects result in the formation of brain tumours, which behave quite similarly in their advanced stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.