ArticleNature chemical biology2011
Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions.
Article in Nature chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Article
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- High throughput screening and metabolic engineering of Saccharopolyspora spinosa for spinosad production.Biotechnology letters · 2025Article
- Enzyme cascades for nucleotide sugar regeneration in glycoconjugate synthesis.Applied microbiology and biotechnology · 2025Review
- Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing.Frontiers in molecular biosciences · 2025Review
- Carbohydrate-active enzyme (CAZyme) discovery and engineeringRSC chemical biology · 2024Review
- Structure-function and engineering of plant UDP-glycosyltransferase.Computational and structural biotechnology journal · 2023Review
- Article
- Controllable Iterative β-Glucosylation from UDP-Glucose byJournal of agricultural and food chemistry · 2021Article
- Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides.Nature communications · 2021Article
- Ginsenosides inActa pharmaceutica Sinica. B · 2021Review
- Effective Generation of Glucosylpiericidins with Selective Cytotoxicities and Insights into Their Biosynthesis.Applied and environmental microbiology · 2021Article
- Photooxidation of thiosaccharides mediated by sensitizers in aerobic and environmentally friendly conditions.RSC advances · 2021Article
- GDP-Mannose 3,5-Epimerase: A View on Structure, Mechanism, and Industrial Potential.Frontiers in molecular biosciences · 2021Review
- EngineerACS catalysis · 2020Article
- OleD Loki as a Catalyst for Hydroxamate Glycosylation.Chembiochem : a European journal of chemical biology · 2020Article
- Cell-Free Synthetic Glycobiology: Designing and Engineering Glycomolecules Outside of Living Cells.Frontiers in chemistry · 2020Review
- Enrichment of Polyglucosylated Isoflavones from Soybean Isoflavone Aglycones Using Optimized Amylosucrase Transglycosylation.Molecules (Basel, Switzerland) · 2020Article
- Leloir Glycosyltransferases in Applied Biocatalysis: A Multidisciplinary Approach.International journal of molecular sciences · 2019Review
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4 authors.
Funding
Abstract
We report that simple glycoside donors can drastically shift the equilibria of glycosyltransferase-catalyzed reactions, transforming NDP-sugar formation from an endothermic to an exothermic process. To demonstrate the utility of this thermodynamic adaptability, we highlight the glycosyltransferase-catalyzed synthesis of 22 sugar nucleotides from simple aromatic sugar donors, as well as the corresponding in situ formation of sugar nucleotides as a driving force in the context of glycosyltransferase-catalyzed reactions for small-molecule glycodiversification. These simple aromatic donors also enabled a general colorimetric assay for glycosyltransfer, applicable to drug discovery, protein engineering and other fundamental sugar nucleotide-dependent investigations. This study directly challenges the general notion that NDP-sugars are 'high-energy' sugar donors when taken out of their traditional biological context.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.