Evidence map›Paper›PMID 21857516›Full record

Trial reportEar and hearing

Comparison of ear-canal reflectance and umbo velocity in patients with conductive hearing loss: a preliminary study.

Hideko H Nakajima, Dominic V Pisano, Christof Roosli, Mohamad A Hamade, Gabrielle R Merchant, Lorice Mahfoud, Christopher F Halpin, John J Rosowski, Saumil N Merchant

Open access · greenAbstract readClinical TrialComparative StudyValidation Study
In one paragraph

Trial report in Ear and hearing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 101 citations in OpenAlex.

  1. Power reflectance as a screening tool for the diagnosis of superior semicircular canal dehiscence.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2015
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  11. [Characteristics and differential diagnosis of middle ear cholesteatoma and chronic suppurative otitis media with wideband acoustic immittance].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
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  12. Mechanics of Total Drum Replacement Tympanoplasty Studied With Wideband Acoustic Immittance.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2022
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  14. Wideband absorbance tympanometry: a novel method in identifying otosclerosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
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  17. [Numerical study on the effect of middle ear malformations on energy absorbance].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021
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  20. Tympanic Resonance Hypothesis.Frontiers in neurology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hideko H NakajimaEaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA. heidi_nakajima@meei.harvard.edu
Dominic V Pisano
Christof Roosli
Mohamad A Hamade
Gabrielle R Merchant
Lorice Mahfoud
Christopher F Halpin
John J Rosowski
Saumil N Merchant
Massachusetts Eye and Ear Infirmary · US

Funding

Middle-ear Mechanics in Normal and Pathological EarsR01DC004798 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI NAKAJIMA, HIDEKO HEIDI · 2001 to 2016
$4.9M
Investigations of Human Auditory MechanicsR03DC011158 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI NAKAJIMA, HIDEKO HEIDI · 2010 to 2012
$492k
NIDCD NIH HHS R01 DC004798NIDCD NIH HHS R03 DC011158
6 · The paper itself

Abstract

objectiveThe goal of the present study was to investigate the clinical utility of measurements of ear-canal reflectance (ECR) in a population of patients with conductive hearing loss in the presence of an intact, healthy tympanic membrane and an aerated middle ear. We also sought to compare the diagnostic accuracy of umbo velocity (VU) measurements and measurements of ECR in the same group of patients.

designThis prospective study comprised 31 adult patients with conductive hearing loss, of which 14 had surgically confirmed stapes fixation due to otosclerosis, 6 had surgically confirmed ossicular discontinuity, and 11 had computed tomography and vestibular evoked myogenic potential confirmed superior semicircular canal dehiscence (SCD). Measurements on all 31 ears included pure-tone audiometry for 0.25 to 8 kHz, ECR for 0.2 to 6 kHz using the Mimosa Acoustics HearID system, and VU for 0.3 to 6 kHz using the HLV-1000 laser Doppler vibrometer (Polytec Inc, Waldbronn, Germany). We analyzed power reflectance |ECR| as well as the absorbance level = 10 × log10(1 - |ECR|). All measurements were made before any surgical intervention. The VU and ECR data were plotted against normative data obtained in a companion study of 58 strictly defined normal ears ().

resultsSmall increases in |ECR| at low-to-mid frequencies (400-1000 Hz) were observed in cases with stapes fixation, while narrowband decreases were seen for both SCD and ossicular discontinuity. The SCD and ossicular discontinuity differed in that the SCD had smaller decreases at mid-frequency (∼1000 Hz), whereas ossicular discontinuity had larger decreases at lower frequencies (500-800 Hz). SCD tended to have less air-bone gap at high frequencies (1-4 kHz) compared with stapes fixation and ossicular discontinuity. The |ECR| measurements, in conjunction with audiometry, could successfully separate 28 of the 31 cases into the three pathologies. By comparison, VU measurements, in conjunction with audiometry, could successfully separate various pathologies in 29 of 31 cases.

conclusionsThe combination of |ECR| with audiometry showed clinical utility in the differential diagnosis of conductive hearing loss in the presence of an intact tympanic membrane and an aerated middle ear and seems to be of similar sensitivity and specificity to measurements of VU plus audiometry. Additional research is needed to expand upon these promising preliminary results.

Indexed as

Acoustic Impedance TestsAdultAgedAudiometry, Pure-ToneEar CanalFemaleHearing Loss, ConductiveHumansMaleMiddle AgedPilot ProjectsPreoperative CareProspective StudiesReproducibility of ResultsSemicircular CanalsSensitivity and Specificity

Identifiers

PMID21857516
PMCPMC3246129
OpenAlexW2042600935

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.