ArticleAnesthesiology2011
Buprenorphine disrupts sleep and decreases adenosine concentrations in sleep-regulating brain regions of Sprague Dawley rat.
Article in Anesthesiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03577730 (Caffeine and Neurologic Recovery Following Surgery and General Anesthesia), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of combining epidural with general anesthesia on postoperative sleep and pain in elderly patients undergoing gastrointestinal tumor surgery: a prospective randomized trial.BMC anesthesiology · 2025Trial
- Sleep reductions associated with illicit opioid use and clinic-hour changes during opioid agonist treatment for opioid dependence: Measurement by electronic diary and actigraphy.Journal of substance abuse treatment · 2019Trial
- Loco-regional fascial blocks in breast-conserving surgery: towards a new standard?Updates in surgery · 2026Article
- Longitudinal dream-content shift and void-like dissociative phenomenology around outpatient ketamine infusions in chronic low back pain: a case report.Journal of medical case reports · 2026Article
- Spontaneous daily sleep disruptions associated with morphine dependence and withdrawal in rats.The Journal of pharmacology and experimental therapeutics · 2025Article
- Perspectives and experiences with sleep and recovery among women receiving buprenorphine for opioid use disorder.PLOS mental health · 2025Article
- Insomnia-related rodent models in drug discovery.Acta pharmacologica Sinica · 2024Review
- Article
- Beneficial Effects of Photoperiod Lengthening on Sleep Characteristics and Mechanical Hyperalgesia in Injured Rats.eNeuro · 2024Article
- Metabotropic glutamate receptor function and regulation of sleep-wake cycles.International review of neurobiology · 2023Article
- Effects of methadone, buprenorphine, and naltrexone on actigraphy-based sleep-like parameters in male rhesus monkeys.Addictive behaviors · 2022Article
- Worsening sleep quality across the lifespan and persistent sleep disturbances in persons with opioid use disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- The relationship between sleep and opioids in chronic pain patients.Journal of behavioral medicine · 2021Article
- Correlates of sleep quality and excessive daytime sleepiness in people with opioid use disorder receiving methadone treatment.Sleep & breathing = Schlaf & Atmung · 2020Article
- Bidirectional Relationship between Opioids and Disrupted Sleep: Putative Mechanisms.Molecular pharmacology · 2020Review
- Optimal Methods of Documenting Analgesic Efficacy in Neonatal Piglets Undergoing Castration.Animals : an open access journal from MDPI · 2020Review
- I'm tired and it hurts! Sleep quality and acute pain response in a chronic pain population.Sleep medicine · 2020Article
- Interacting Influences of Sleep, Pain, and Analgesic Medications on Sleep Studies in Rodents.Comparative medicine · 2019Review
- Buprenorphine Depresses Respiratory Variability in Obese Mice with Altered Leptin Signaling.Anesthesiology · 2018Article
- Frequency and correlates of sleep disturbance in methadone and buprenorphine-maintained patients.Addictive behaviors · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBuprenorphine, a partial μ-opioid receptor agonist and κ-opioid receptor antagonist, is an effective analgesic. The effects of buprenorphine on sleep have not been well characterized. This study tested the hypothesis that an antinociceptive dose of buprenorphine decreases sleep and decreases adenosine concentrations in regions of the basal forebrain and pontine brainstem that regulate sleep.
methodsMale Sprague Dawley rats were implanted with intravenous catheters and electrodes for recording states of wakefulness and sleep. Buprenorphine (1 mg/kg) was administered systemically via an indwelling catheter and sleep-wake states were recorded for 24 h. In additional rats, buprenorphine was delivered by microdialysis to the pontine reticular formation and substantia innominata of the basal forebrain while adenosine was simultaneously measured.
resultsAn antinociceptive dose of buprenorphine caused a significant increase in wakefulness (25.2%) and a decrease in nonrapid eye movement sleep (-22.1%) and rapid eye movement sleep (-3.1%). Buprenorphine also increased electroencephalographic delta power during nonrapid eye movement sleep. Coadministration of the sedative-hypnotic eszopiclone diminished the buprenorphine-induced decrease in sleep. Dialysis delivery of buprenorphine significantly decreased adenosine concentrations in the pontine reticular formation (-14.6%) and substantia innominata (-36.7%). Intravenous administration of buprenorphine significantly decreased (-20%) adenosine in the substantia innominata.
conclusionsBuprenorphine significantly increased time spent awake, decreased nonrapid eye movement sleep, and increased latency to sleep onset. These disruptions in sleep architecture were mitigated by coadministration of the nonbenzodiazepine sedative-hypnotic eszopiclone. The buprenorphine-induced decrease in adenosine concentrations in basal forebrain and pontine reticular formation is consistent with the interpretation that decreasing adenosine in sleep-regulating brain regions is one mechanism by which opioids disrupt sleep.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.