Evidence map›Paper›PMID 21857158›Full record

ArticleCell cycle (Georgetown, Tex.)2011

Hematopoietic cells as sources for patient-specific iPSCs and disease modeling.

Zhaohui Ye, Cyndi F Liu, Yoon-Young Jang

Open access · bronzeAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zhaohui YeDivision of Hematology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. zye@jhmi.edu
Cyndi F Liu
Yoon-Young Jang
Johns Hopkins Medicine · USUniversity of Baltimore · US

Funding

TRAINING PROGRAM IN HEMATOLOGYT32HL007525 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ROBERT A BRODSKY · 1985 to 2026
$6.2M
DISEASE MODELING OF ALCOHOL RELATED HEPATOCELLULAR CARCINOMA USING PATIENT IPSCSR21AA020020 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI JANG, YOON YOUNG · 2011 to 2012
$431k
Ultraminiaturized microfluidics-based drug toxicity screening platform using iPSCR43ES023514 · NIEHS · EUVEDA BIOSCIENCES, INC. · PI JANG, YOON YOUNG, YIN, ZHIZHONG · 2013 to 2013
$225k
NHLBI NIH HHS 5T32HL007525-27NHLBI NIH HHS T32 HL007525NIAAA NIH HHS R21 AA020020NIEHS NIH HHS R43 ES023514PHS HHS 109577
6 · The paper itself

Abstract

In addition to being an attractive source for cell replacement therapy, human induced pluripotent stem cells (iPSCs) also have great potential for disease modeling and drug development. During the recent several years, cell reprogramming technologies have evolved to generate virus-free and integration-free human iPSCs from easily accessible sources such as patient skin fibroblasts and peripheral blood samples. Hematopoietic cells from umbilical cord blood banks and Epstein Barr virus (EBV) immortalized B lymphocyte repositories represent alternative sources for human genetic materials of diverse backgrounds. Ability to reprogram these banked blood cells to pluripotency and differentiate them into a variety of specialized and functional cell types provides valuable tools for studying underlying mechanisms of a broad range of diseases including rare inherited disorders. Here we describe the recent advances in generating disease specific human iPSCs from these different types of hematopoietic cells and their potential applications in disease modeling and regenerative medicine.

Indexed as

Blood BanksB-LymphocytesCell DifferentiationCell ProliferationCellular ReprogrammingEpigenesis, GeneticFetal BloodHematopoietic Stem CellsHerpesvirus 4, HumanHumansInduced Pluripotent Stem Cells

Identifiers

PMID21857158
PMCPMC3218597
OpenAlexW1968129027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.