Evidence map›Paper›PMID 21857119›Full record

ReviewJournal of biosciences2011

Nucleic acid therapy for lifespan prolongation: present and future.

Wing-Fu Lai

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of biosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Use of graphene-based materials as carriers of bioactive agents.Asian journal of pharmaceutical sciences · 2021
    Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. We are ageing.BioMed research international · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Wing-Fu LaiDepartment of Chemistry, The University of Hong Kong, Hong Kong Special Administrative Region, China. rori0610@graduate.hku.hk

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lifespan prolongation is a common desire of the human race. With advances in biotechnology, the mechanism of aging has been gradually unraveled, laying the theoretical basis of nucleic acid therapy for lifespan prolongation. Regretfully, clinically applicable interventions do not exist without the efforts of converting theory into action, and it is the latter that has been far from adequately addressed at the moment. This was demonstrated by a database search on PubMed and Web of Science, from which only seven studies published between 2000 and 2010 were found to directly touch on the development of nucleic acid therapy for anti-aging and/or longevity enhancing purposes. In light of this, the objective of this article is to overview the current understanding of the intimate association between genes and longevity, and to bring the prospect of nucleic acid therapy for lifespan prolongation to light.

Indexed as

LongevityNucleic AcidsAnimalsBibliographies as TopicCaenorhabditis elegansDrosophila melanogasterForecastingHumansLife ExpectancyMiceSignal TransductionYeastsNucleic Acids

Identifiers

PMID21857119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.