ArticleJournal of biosciences2011
Analysis of phage Mu DNA transposition by whole-genome Escherichia coli tiling arrays reveals a complex relationship to distribution of target selection protein B, transcription and chromosome architectural elements.
Article in Journal of biosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- High-Throughput Mapping of Chromosomal Conformations in E. coli Under Physiological Conditions Using Massively Multiplexed Mu Transposition.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Mechanism of target site selection by type V-K CRISPR-associated transposases.Science (New York, N.Y.) · 2023Article
- Deep sequencing reveals new roles for MuB in transposition immunity and target-capture, and redefines the insular Ter region ofMobile DNA · 2020Article
- Endogenous and Foreign Nucleoid-Associated Proteins of Bacteria: Occurrence, Interactions and Effects on Mobile Genetic Elements and Host's Biology.Computational and structural biotechnology journal · 2019Review
- Article
- Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal.eLife · 2017Article
- Unlocking Tn3-family transposase activity in vitro unveils an asymetric pathway for transposome assembly.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Repair of transposable phage Mu DNA insertions begins only when the E. coli replisome collides with the transpososome.Molecular microbiology · 2015Article
- Transposable Phage Mu.Microbiology spectrum · 2014Review
- Transposable prophage Mu is organized as a stable chromosomal domain of E. coli.PLoS genetics · 2013Article
- Mu insertions are repaired by the double-strand break repair pathway of Escherichia coli.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Of all known transposable elements, phage Mu exhibits the highest transposition efficiency and the lowest target specificity. In vitro, MuB protein is responsible for target choice. In this work, we provide a comprehensive assessment of the genome-wide distribution of MuB and its relationship to Mu target selection using high-resolution Escherichia coli tiling DNA arrays. We have also assessed how MuB binding and Mu transposition are influenced by chromosome-organizing elements such as AT-rich DNA signatures, or the binding of the nucleoid-associated protein Fis, or processes such as transcription. The results confirm and extend previous biochemical and lower resolution in vivo data. Despite the generally random nature of Mu transposition and MuB binding, there were hot and cold insertion sites and MuB binding sites in the genome, and differences between the hottest and coldest sites were large. The new data also suggest that MuB distribution and subsequent Mu integration is responsive to DNA sequences that contribute to the structural organization of the chromosome.
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Registered trials
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