ArticleJournal of bacteriology2011
The Bacillus subtilis GntR family repressor YtrA responds to cell wall antibiotics.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Disruption of ytrE attenuates methicillin-resistant Staphylococcus aureus virulence and compromises membrane integrity and oxidative stress resistance.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Structural analysis of a Gram-positive type VII ABC transporter induced by cell wall-targeting antibiotics.Structure (London, England : 1993) · 2026Article
- Contribution of theMicrobiology spectrum · 2026Article
- Lydicamycins induce morphological differentiation in actinobacterial interactions.Applied and environmental microbiology · 2025Article
- Genomic Insights into Selenate Reduction byMicroorganisms · 2025Article
- Localization and Single Molecule Dynamics ofCells · 2025Article
- Phosphorylation of GntR reduces Streptococcus suis oxidative stress resistance and virulence by inhibiting NADH oxidase transcription.PLoS pathogens · 2023Article
- The quorum sensing peptide BlpC regulates the transcription of genes outside its associated gene cluster and impacts the growth ofFrontiers in microbiology · 2023Article
- Combating multidrug-resistant Helicobacter pylori with moenomycin A in combination with clarithromycin or metronidazole.Frontiers in chemistry · 2022Article
- Structural diversity, bioactivity, and biosynthesis of phosphoglycolipid family antibiotics: Recent advances.BBA advances · 2022Article
- Deficiency of GntR Family Regulator MSMEG_5174 PromotesFrontiers in microbiology · 2022Article
- Not Just Transporters: Alternative Functions of ABC Transporters inMicroorganisms · 2021Review
- Influence of the ABC Transporter YtrBCDEF ofFrontiers in microbiology · 2021Article
- Transcriptomic Evidence of Molecular Mechanisms Underlying the Response of Lactobacillus Plantarum WCFS1 to Hydroxytyrosol.Antioxidants (Basel, Switzerland) · 2020Article
- YtrAFrontiers in microbiology · 2019Article
- Induction of the Spx regulon by cell wall stress reveals novel regulatory mechanisms in Bacillus subtilis.Molecular microbiology · 2018Article
- Deciphering the regulon of a GntR family regulator via transcriptome and ChIP-exo analyses and its contribution to virulence in Xanthomonas citri.Molecular plant pathology · 2017Article
- RodA as the missing glycosyltransferase in Bacillus subtilis and antibiotic discovery for the peptidoglycan polymerase pathway.Nature microbiology · 2017Article
- Depletion of Undecaprenyl Pyrophosphate Phosphatases Disrupts Cell Envelope Biogenesis in Bacillus subtilis.Journal of bacteriology · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
The transglycosylation step of cell wall synthesis is a prime antibiotic target because it is essential and specific to bacteria. Two antibiotics, ramoplanin and moenomycin, target this step by binding to the substrate lipid II and the transglycosylase enzyme, respectively. Here, we compare the ramoplanin and moenomycin stimulons in the Gram-positive model organism Bacillus subtilis. Ramoplanin strongly induces the LiaRS two-component regulatory system, while moenomycin almost exclusively induces genes that are part of the regulon of the extracytoplasmic function (ECF) σ factor σ(M). Ramoplanin additionally induces the ytrABCDEF and ywoBCD operons, which are not part of a previously characterized antibiotic-responsive regulon. Cluster analysis reveals that these two operons are selectively induced by a subset of cell wall antibiotics that inhibit lipid II function or recycling. Repression of both operons requires YtrA, which recognizes an inverted repeat in front of its own operon and in front of ywoB. These results suggest that YtrA is an additional regulator of cell envelope stress responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.