ArticleApplied and environmental microbiology2011
β-lactams and florfenicol antibiotics remain bioactive in soils while ciprofloxacin, neomycin, and tetracycline are neutralized.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 90 citations in OpenAlex.
- Effects of florfenicol on linezolid resistance in Enterococcus faecium from waterfowl farms.Poultry science · 2026Article
- Effect of alkaline pretreatment on cephalosporin degradation and microbial susceptibility in wastewater of cephalosporin drug manufacturing plant.Scientific reports · 2026Article
- Strategies to reduce antimicrobials in livestock and aquaculture, and their impact under field conditions: a structured scoping literature review.The Journal of antimicrobial chemotherapy · 2024Article
- Development and Evaluation of EDTA-Treated Rabbits for Bioavailability Study of Chelating Drugs Using Levofloxacin, Ciprofloxacin, Hemiacetal Ester Prodrugs, and Tetracycline.Pharmaceutics · 2023Article
- Detection of anAntibiotics (Basel, Switzerland) · 2022Article
- Excreted Antibiotics May Be Key to Emergence of Increasingly Efficient Antibiotic Resistance in Food Animal Production.Applied and environmental microbiology · 2022Article
- Strategies for Enzymatic Inactivation of the Veterinary Antibiotic Florfenicol.Antibiotics (Basel, Switzerland) · 2022Article
- Antibiotic resistant bacteria: A bibliometric review of literature.Frontiers in public health · 2022Review
- Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 7:EFSA journal. European Food Safety Authority · 2021Article
- Identification of the Multiresistance GenePathogens (Basel, Switzerland) · 2021Article
- Antibiotics in the environment: causes and consequences.Medicine and pharmacy reports · 2020Review
- Deploying Elemental Iodine in a Vapor Form to Disinfect Water and to Clear Biofilms.International journal of environmental research and public health · 2020Article
- Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania.Nature communications · 2020Article
- Dairy farm soil presents distinct microbiota and varied prevalence of antibiotic resistance across housing areas.Environmental pollution (Barking, Essex : 1987) · 2019Article
- Dynamic transport of antibiotics and antibiotic resistance genes under different treatment processes in a typical pharmaceutical wastewater treatment plant.Environmental science and pollution research international · 2018Article
- Cu(II)-catalyzed degradation of ampicillin: effect of pH and dissolved oxygen.Environmental science and pollution research international · 2018Article
- Models of antimicrobial pressure on intestinal bacteria of the treated host populations.Epidemiology and infection · 2017Article
- Prevalence and Abundance of Florfenicol and Linezolid Resistance Genes in Soils Adjacent to Swine Feedlots.Scientific reports · 2016Article
- Veterinary Medicine Needs New Green Antimicrobial Drugs.Frontiers in microbiology · 2016Review
- Ciprofloxacin residues in municipal biosolid compost do not selectively enrich populations of resistant bacteria.Applied and environmental microbiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
It is generally assumed that antibiotic residues in soils select for antibiotic-resistant bacteria. This assumption was tested by separately adding 10 different antibiotics (≥200 ppm) to three soil-water slurries (silt-loam, sand-loam, and sand; 20% soil [wt/vol]) and incubating mixtures for 24 h at room temperature. The antibiotic activity of the resultant supernatant was assessed by culturing a sensitive Escherichia coli strain in the filter-sterilized supernatant augmented with Luria-Bertani broth. We found striking differences in the abilities of supernatants to suppress growth of the indicator E. coli. Ampicillin, cephalothin, cefoxitin, ceftiofur, and florfenicol supernatants completely inhibited growth while bacterial growth was uninhibited in the presence of neomycin, tetracycline, and ciprofloxacin supernatants. High-performance liquid chromatography (HPLC) analysis demonstrated that cefoxitin and florfenicol were almost completely retained in the supernatants, whereas tetracycline and ciprofloxacin were mostly removed. Antibiotic dissipation in soil, presumably dominated by adsorption mechanisms, was sufficient to neutralize 200 ppm of tetracycline; this concentration is considerably higher than reported contamination levels. Soil pellets from the tetracycline slurries were resuspended in a minimal volume of medium to maximize the interaction between bacteria and soil particles, but sensitive bacteria were still unaffected by tetracycline (P = 0.6). Thus, residual antibiotics in soil do not necessarily exert a selective pressure, and the degree to which the pharmaceutical remains bioactive depends on the antibiotic. Efforts to control antibiotic contamination would be better directed toward compounds that retain biological activity in soils (e.g., cephalosporins and florfenicol) because these are the antibiotics that could exert a selective pressure in the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.