ArticleGenes & development2011
mir-11 limits the proapoptotic function of its host gene, dE2f1.
Article in Genes & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- A Compilation of the Diverse miRNA Functions inInternational journal of molecular sciences · 2023Review
- Enthralling genetic regulatory mechanisms meddling insecticide resistance development in insects: role of transcriptional and post-transcriptional events.Frontiers in molecular biosciences · 2023Review
- Distinct and Coordinated Regulation of Small Non-coding RNAs by E2f1 and p53 DuringFrontiers in cell and developmental biology · 2021Article
- lncRNA MIR22HG-Derived miR-22-5p Enhances the Radiosensitivity of Hepatocellular Carcinoma by Increasing Histone Acetylation Through the Inhibition of HDAC2 Activity.Frontiers in oncology · 2021Article
- Aberration of the modulatory functions of intronic microRNA hsa-miR-933 on its host gene ATF2 results in type II diabetes mellitus and neurodegenerative disease development.Human genomics · 2020Article
- TheDevelopment (Cambridge, England) · 2018Article
- Identification and Functional Characterization of Long Non-coding RNATheranostics · 2018Article
- Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs.Cell reports · 2017Article
- MicroRNA function in Drosophila melanogaster.Seminars in cell & developmental biology · 2017Review
- Infections of virulent and avirulent viruses differentially influenced the expression of dicer-1, ago-1, and microRNAs in Bombus terrestris.Scientific reports · 2017Article
- Rs3842530 Polymorphism in MicroRNA-205 Host Gene in Lung and Breast Cancer Patients.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Novel regulation and functional interaction of polycistronic miRNAs.RNA (New York, N.Y.) · 2016Article
- Regulation of Cell Death by IAPs and Their Antagonists.Current topics in developmental biology · 2015Review
- An intronic microRNA links Rb/E2F and EGFR signaling.PLoS genetics · 2014Article
- Co-activation of microRNAs by Zelda is essential for early Drosophila development.Development (Cambridge, England) · 2014Article
- Noncoding RNAs in DNA repair and genome integrity.Antioxidants & redox signaling · 2014Review
- Loss of dE2F compromises mitochondrial function.Developmental cell · 2013Article
- Article
- Insect microRNAs: biogenesis, expression profiling and biological functions.Insect biochemistry and molecular biology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The E2F family of transcription factors regulates the expression of both genes associated with cell proliferation and genes that regulate cell death. The net outcome is dependent on cellular context and tissue environment. The mir-11 gene is located in the last intron of the Drosophila E2F1 homolog gene dE2f1, and its expression parallels that of dE2f1. Here, we investigated the role of miR-11 and found that miR-11 specifically modulated the proapoptotic function of its host gene, dE2f1. A mir-11 mutant was highly sensitive to dE2F1-dependent, DNA damage-induced apoptosis. Consistently, coexpression of miR-11 in transgenic animals suppressed dE2F1-induced apoptosis in multiple tissues, while exerting no effect on dE2F1-driven cell proliferation. Importantly, miR-11 repressed the expression of the proapoptotic genes reaper (rpr) and head involution defective (hid), which are directly regulated by dE2F1 upon DNA damage. In addition to rpr and hid, we identified a novel set of cell death genes that was also directly regulated by dE2F1 and miR-11. Thus, our data support a model in which the coexpression of miR-11 limits the proapoptotic function of its host gene, dE2f1, upon DNA damage by directly modulating a dE2F1-dependent apoptotic transcriptional program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.