ArticleGenes & development2011
A novel mechanism for the transcriptional regulation of Wnt signaling in development.
Article in Genes & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 74 citations in OpenAlex.
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- TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain.Molecular psychiatry · 2023Article
- Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant.Experimental & molecular medicine · 2023Article
- Integrated analysis of Wnt signalling system component gene expression.Development (Cambridge, England) · 2022Article
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- Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment.Cell reports · 2021Article
- TCF7L2 silencing results in altered gene expression patterns accompanied by local genomic reorganization.Neoplasia (New York, N.Y.) · 2021Article
- 3D Hybrid Nanofiber Aerogels Combining with Nanoparticles Made of a Biocleavable and Targeting Polycation and MiR-26a for Bone Repair.Advanced functional materials · 2020Article
- TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus.Development (Cambridge, England) · 2020Article
- AlternativeFrontiers in immunology · 2020Article
- Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling.PloS one · 2020Article
- Developmentally regulatedeLife · 2019Article
- Article
- Global Analysis of Intercellular Homeodomain Protein Transfer.Cell reports · 2019Article
- Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models.Disease models & mechanisms · 2019Review
- Article
- The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function.Diabetes · 2018Article
- KDM2A/B lysine demethylases and their alternative isoforms in development and disease.Nucleus (Austin, Tex.) · 2018Review
- A demethylation deficient isoform of the lysine demethylase KDM2A interacts with pericentromeric heterochromatin in an HP1a-dependent manner.Nucleus (Austin, Tex.) · 2017Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Axial patterning of the embryonic brain requires a precise balance between canonical Wnt signaling, which dorsalizes the nervous system, and Sonic hedgehog (Shh), which ventralizes it. The ventral anterior homeobox (Vax) transcription factors are induced by Shh and ventralize the forebrain through a mechanism that is poorly understood. We therefore sought to delineate direct Vax target genes. Among these, we identify an extraordinarily conserved intronic region within the gene encoding Tcf7l2, a key mediator of canonical Wnt signaling. This region functions as a Vax2-activated internal promoter that drives the expression of dnTcf7l2, a truncated Tcf7l2 isoform that cannot bind β-catenin and that therefore acts as a potent dominant-negative Wnt antagonist. Vax2 concomitantly activates the expression of additional Wnt antagonists that cooperate with dnTcf7l2. Specific elimination of dnTcf7l2 in Xenopus results in headless embryos, a phenotype consistent with a fundamental role for this regulator in forebrain development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.