SynthesisThorax2012
Occupational exposure to organic dust increases lung cancer risk in the general population.
Synthesis in Thorax, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The effect of occupational exposure to organic dust on lung function parameters among African industrial workers: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure-response relationships.Scandinavian journal of work, environment & health · 2024Article
- Lung cancer risk in relation to jobs held in a nationwide case-control study in Iran.Occupational and environmental medicine · 2022Article
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- Article
- Females and Males Show Differences in Early-Stage Transcriptomic Biomarkers of Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2021Article
- Occupational exposure and the risk of airway obstruction and mortality.International journal of public health · 2020Article
- Cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) polymorphism reduces risk of lung cancer: A meta-analysis.Tobacco induced diseases · 2020Review
- Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling.Respiratory research · 2019Article
- Downregulation of exosomal let-7a-5p in dust exposed- workers contributes to lung cancer development.Respiratory research · 2018Article
- Industrial hog farming is associated with altered circulating immunological markers.Occupational and environmental medicine · 2018Article
- Occupational exposure to endotoxins and lung cancer risk: results of the ICARE Study.Occupational and environmental medicine · 2017Article
- Epidemiology in Germany-general development and personal experience.European journal of epidemiology · 2017Article
- Morbidity and mortality of people who live close to municipal waste landfills: a multisite cohort study.International journal of epidemiology · 2016Article
- Evaluation of the Survivability of Microorganisms Deposited on Filtering Respiratory Protective Devices under Varying Conditions of Humidity.International journal of environmental research and public health · 2016Article
- Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies.Scandinavian journal of work, environment & health · 2015Article
- Lack of a protective effect of cotton dust on risk of lung cancer: evidence from two population-based case-control studies.BMC cancer · 2015Article
- Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers.British journal of cancer · 2014Article
- Lung cancer correlates in Lebanese adults: a pilot case--control study.Journal of epidemiology and global health · 2013Article
- Lung cancer risk among hairdressers: a pooled analysis of case-control studies conducted between 1985 and 2010.American journal of epidemiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 20 institutions in 13 countries.
Funding
Abstract
backgroundOrganic dust is a complex mixture of particulate matter from microbial, plant or animal origin. Occupations with exposure to animal products have been associated with an increased lung cancer risk, while exposure to microbial components (eg, endotoxin) has been associated with a decreased risk. To date there has not been a comprehensive evaluation of the possible association between occupational organic dust exposure (and its specific constituents) and lung cancer risk in the general population.
methodsThe SYNERGY project has pooled information on lifetime working and smoking from 13 300 lung cancer cases and 16 273 controls from 11 case-control studies conducted in Europe and Canada. A newly developed general population job-exposure matrix (assigning no, low or high exposure to organic dust, endotoxin, and contact with animals or fresh animal products) was applied to determine level of exposure. ORs for lung cancer were estimated by logistic regression, adjusted for age, sex, study, cigarette pack-years, time since quitting smoking, and ever employment in occupations with established lung cancer risk.
resultsOccupational organic dust exposure was associated with increased lung cancer risk. The second to the fourth quartile of cumulative exposure showed significant risk estimates ranging from 1.12 to 1.24 in a dose-dependent manner (p<0.001). This association remained in the highest quartile after restricting analyses to subjects without chronic obstructive pulmonary disease or asthma. No association was observed between lung cancer and exposure to endotoxin or contact with animals or animal products.
conclusionOccupational exposure to organic dust was associated with increased lung cancer risk in this large pooled case-control study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.