ArticleGenome biology and evolution2011
Reduced efficacy of natural selection on codon usage bias in selfing Arabidopsis and Capsella species.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Plastomes of TenEcology and evolution · 2026Article
- Synonymous Codons as Potential Contributors to Chromatin Stability and Gene Body Methylation in Plants.Journal of molecular evolution · 2026Article
- Integrative genomic and machine learning approaches reveal evolutionary signatures in the winged bean mitochondrial genome.BMC plant biology · 2025Article
- A model of Hill-Robertson interference caused by purifying selection in a nonrecombining genome.Genetics · 2025Article
- Evolution of theEcology and evolution · 2025Article
- Complete chloroplast genome of eight Phaius (Orchidaceae) species from China: comparative analysis and phylogenetic relationship.BMC plant biology · 2025Article
- Complete chloroplast genome structural characterization of two Aerides (Orchidaceae) species with a focus on phylogenetic position of Aerides flabellata.BMC genomics · 2024Article
- Codon usage characterization and phylogenetic analysis of the mitochondrial genome in Hemerocallis citrina.BMC genomic data · 2024Article
- The evolutionary characterization of Gamasida based on mitochondrial genes codon usage pattern.Parasitology research · 2023Article
- An analysis of codon utilization patterns in the chloroplast genomes of three species of Coffea.BMC genomic data · 2023Article
- Complete chloroplast genome structural characterization of two Phalaenopsis (Orchidaceae) species and comparative analysis with their alliance.BMC genomics · 2023Article
- Comparative analysis of codon usage patterns in chloroplast genomes of ten Epimedium species.BMC genomic data · 2023Article
- Analysis of codon usage bias of WRKY transcription factors in Helianthus annuus.BMC genomic data · 2022Article
- Gene Body Methylation in Plants: Mechanisms, Functions, and Important Implications for Understanding Evolutionary Processes.Genome biology and evolution · 2022Review
- Codon usage bias.Molecular biology reports · 2022Review
- Genome-wide analysis of codon usage in sesame (Heliyon · 2022Article
- Article
- Context-dependent and -independent selection on synonymous mutations revealed by 1,135 genomes of Arabidopsis thaliana.BMC ecology and evolution · 2021Article
- Cost-efficiency tradeoff is optimized in various cancer types revealed by genome-wide analysis.Molecular genetics and genomics : MGG · 2021Article
- The Genomic Selfing Syndrome Accompanies the Evolutionary Breakdown of Heterostyly.Molecular biology and evolution · 2021Article
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5 authors.
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Abstract
Population genetic theory predicts that the efficacy of natural selection in a self-fertilizing species should be lower than its outcrossing relatives because of the reduction in the effective population size (N(e)) in the former brought about by inbreeding. However, previous analyses comparing Arabidopsis thaliana (selfer) with A. lyrata (outcrosser) have not found conclusive support for this prediction. In this study, we addressed this issue by examining silent site polymorphisms (synonymous and intronic), which are expected to be informative about changes in N(e). Two comparisons were made: A. thaliana versus A. lyrata and Capsella rubella (selfer) versus C. grandiflora (outcrosser). Extensive polymorphism data sets were obtained by compiling published data from the literature and by sequencing 354 exon loci in C. rubella and 89 additional loci in C. grandiflora. To extract information from the data effectively for studying these questions, we extended two recently developed models in order to investigate detailed selective differences between synonymous codons, mutational biases, and biased gene conversion (BGC), taking into account the effects of recent changes in population size. We found evidence that selection on synonymous codons is significantly weaker in the selfers compared with the outcrossers and that this difference cannot be fully accounted for by mutational biases or BGC.
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