ArticleFree radical biology & medicine2011
Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages.
Article in Free radical biology & medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Arachidonic acid metabolism in health and disease.MedComm · 2023Review
- Aspirin eugenol ester ameliorates LPS-induced inflammatory responses in RAW264.7 cells and mice.Frontiers in pharmacology · 2023Article
- Neuroprotective effect of aldose reductase knockout in a mouse model of spinal cord injury involves NF-κB pathway.Experimental brain research · 2022Article
- Angong Niuhuang Pill ameliorates cerebral ischemia/reperfusion injury in mice partly by restoring gut microbiota dysbiosis.Frontiers in pharmacology · 2022Article
- Aldose reductase deficiency inhibits LPS-induced M1 response in macrophages by activating autophagy.Cell & bioscience · 2021Article
- Human Aldose Reductase Expression Prevents Atherosclerosis Regression in Diabetic Mice.Diabetes · 2018Article
- Inhibition of leukotriene B4 receptor 1 attenuates lipopolysaccharide-induced cardiac dysfunction: role of AMPK-regulated mitochondrial function.Scientific reports · 2017Article
- Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins.Journal of diabetes research · 2017Article
- Successful reduction of inflammatory responses and arachidonic acid-cyclooxygenase 2 pathway in human pulmonary artery endothelial cells by silencing adipocyte fatty acid-binding protein.Journal of inflammation (London, England) · 2017Article
- Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug.Toxicology research · 2016Article
- Anti-Inflammation Effects and Potential Mechanism of Saikosaponins by Regulating Nicotinate and Nicotinamide Metabolism and Arachidonic Acid Metabolism.Inflammation · 2016Article
- Synergistic Effect of Compounds from a Chinese Herb: Compatibility and Dose Optimization of Compounds from N-Butanol Extract of Ipomoea stolonifera.Scientific reports · 2016Article
- Aldose reductase participates in the downregulation of T cell functions due to suppressor macrophages.Scientific reports · 2016Article
- Immune Cells and Inflammation in Diabetic Nephropathy.Journal of diabetes research · 2016Review
- Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway.Inflammation · 2015Article
- Comparing efficacy of Montelukast versus doxycycline in treatment of moderate acne.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
- Novel insights into the mechanisms whereby isoflavones protect against fatty liver disease.World journal of gastroenterology · 2015Review
- Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors.Free radical biology & medicine · 2013Article
- Deletion of aldose reductase from mice inhibits diabetes-induced retinal capillary degeneration and superoxide generation.PloS one · 2013Article
- Regulation of aldo-keto reductases in human diseases.Frontiers in pharmacology · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The bacterial endotoxin lipopolysaccharide (LPS) is known to induce release of arachidonic acid (AA) and its metabolic products, which play important roles in the inflammatory process. We have shown earlier that LPS-induced signals in macrophages are mediated by aldose reductase (AR). Here we have investigated the role of AR in LPS-induced release of AA metabolites and their modulation using a potent pharmacological inhibitor, fidarestat, and AR siRNA ablation in RAW264.7 macrophages and AR-knockout mouse peritoneal macrophages and heart tissue. Inhibition or genetic ablation of AR prevented the LPS-induced synthesis and release of AA metabolites such as PGE2, TXB, PGI2, and LTBs in macrophages. LPS-induced activation of cPLA2 was also prevented by AR inhibition. Similarly, AR inhibition also prevented the calcium ionophore A23187-induced cPLA2 and LTB4 in macrophages. Further, AR inhibition by fidarestat prevented the expression of AA-metabolizing enzymes such as COX-2 and LOX-5 in RAW264.7 cells and AR-knockout mouse-derived peritoneal macrophages. LPS-induced expression of AA-metabolizing enzymes and their catalyzed metabolic products was significantly lower in peritoneal macrophages and heart tissue from AR-knockout mice. LPS-induced activation of redox-sensitive signaling intermediates such as MAPKs, transcription factor NF-κB, and EGR-1, a transcriptional regulator of mPGES-1, which in collaboration with COX-2 leads to the production of PGE2, was also significantly prevented by AR inhibition. Taken together, our results indicate that AR mediates LPS-induced inflammation by regulating the AA-metabolic pathway and thus provide a novel role for AR inhibition in preventing inflammatory complications such as sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.