Evidence map›Paper›PMID 21856073›Full record

ArticleUltrasound in medicine & biology2011

Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments.

Carl D Herickhoff, Christy M Wilson, Gerald A Grant, Gavin W Britz, Edward D Light, Mark L Palmeri, Patrick D Wolf, Stephen W Smith

Open access · greenAbstract read
In one paragraph

Article in Ultrasound in medicine & biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. A 9-Fr Endovascular Therapy Transducer With an Acoustic Metamaterial Lens for Rapid Stroke Thrombectomy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024
    Article
  2. Article
  3. Dual-Frequency Piezoelectric Endoscopic Transducer for Imaging Vascular Invasion in Pancreatic Cancer.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017
    Article
  4. Article
  5. Article
  6. Article
  7. An IVUS transducer for microbubble therapies.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2014
    Article
  8. Article
  9. Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Carl D HerickhoffDepartment of Biomedical Engineering, Duke University Medical Center, Durham, NC 27708, USA. cdh14@duke.edu
Christy M Wilson
Gerald A Grant
Gavin W Britz
Edward D Light
Mark L Palmeri
Patrick D Wolf
Stephen W Smith
Duke Medical Center · US

Funding

3D Ultrasound Guidance of Interventional DevicesR01HL089507 · NHLBI · DUKE UNIVERSITY · PI SMITH, STEPHEN WILLIAM · 2008 to 2012
$2.8M
NHLBI NIH HHS HL089507NHLBI NIH HHS R01 HL089507
6 · The paper itself

Abstract

In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 × 0.5 × 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5°C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument.

Indexed as

TransducersAnimalsBrain NeoplasmsCerebral AngiographyDisease Models, AnimalEquipment DesignFeasibility StudiesGlioblastomaHyperthermia, InducedMiceMice, NudePhantoms, ImagingSheep, DomesticSurgery, Computer-AssistedSwineUltrasonography, Interventional

Identifiers

PMID21856073
PMCPMC3177008
OpenAlexW2139401547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.