ArticleOphthalmology2011
The effect of cancer therapies on pediatric anophthalmic sockets.
Article in Ophthalmology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of selected musculoskeletal late effects in survivors of childhood cancer.Current pediatric reviews · 2014Pooled it
- Quality of Life (QoL) and Psychosocial Outcomes in Adult Survivors of Unilateral Retinoblastoma (RB) in China.Journal of ophthalmology · 2020Article
- Porous orbital implant after enucleation in retinoblastoma patients: indications and complications.Orbit (Amsterdam, Netherlands) · 2018Article
- Effects on Periocular Tissues after Proton Beam Radiation Therapy for Intraocular Tumors.Journal of Korean medical science · 2018Article
- Worldwide enucleation techniques and materials for treatment of retinoblastoma: an international survey.PloS one · 2015Article
- Management of radiation-induced severe anophthalmic socket contracture in patients with uveal melanoma.Ophthalmic plastic and reconstructive surgeryArticle
- Orbital pathology - Iatrogenic findings and artefacts.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeTo determine the impact of chemotherapy or external beam radiotherapy (EBRT) on pediatric anophthalmic sockets.
designA retrospective, nonrandomized, interventional cohort study.
participantsA total of 135 sockets of 133 children undergoing enucleation from late 1999 to early 2009 at the St. Jude Children's Research Hospital were included.
methodsA retrospective chart review of outcomes after enucleation in patients treated with systemic chemotherapy or orbital EBRT either before or after removal of the eye compared with patients who received no other treatment.
main outcome measuresIncidence of implant exposure, migration, extrusion, socket contracture, and pyogenic granuloma formation.
resultsRetinoblastoma was the primary diagnosis in 128 eyes (95%). Median follow-up was 3.6 years (range, 0.1-9.3 years). Event-free course was observed in 94 sockets (69.6%). Complications included implant exposure (n = 28, 20.7%), socket contracture (n = 16, 11.9%), pyogenic granuloma (n = 9, 6.7%), implant extrusion (n = 3, 2.2%), and migration (n = 2, 1.5%). Exposure resolved in 21 sockets (77.8%) and improved in 2 sockets (11.1%); 1 patient with exposure died. Use of prior, adjuvant, or subsequent chemotherapy increased the long-term risk of exposure (odds ratio [OR] = 3.7; 95% confidence interval [CI], 1.4-9.4), and contracture (OR could not be calculated, P<0.0001). External beam radiotherapy greatly increased the risk of contracture (OR 24.0; 95% CI, 6.9-82.8) and exposure (OR 2.89; 95% CI, 1.1-7.9).
conclusionsIn this unique pediatric population with cancer, chemotherapy and EBRT had an additive effect, significantly increasing the incidence of exposure and socket contracture. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
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