ArticleBiological psychiatry2012
Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026Article
- Hidden variables in stress neurobiology research.Trends in neurosciences · 2024Review
- Whole Transcriptome Analysis of Hypothalamus in Mice during Short-Term Starvation.International journal of molecular sciences · 2023Article
- Pharmacological activation of the amygdala, but not single prolonged footshock-induced acute stress, interferes with cue-induced motivation toward food rewards in rats.Frontiers in behavioral neuroscience · 2023Article
- Long-Term Calorie Restriction Alters Anxiety-like Behaviour and the Brain and Adrenal Gland Transcriptomes of the Ageing Male Rat.Nutrients · 2022Article
- Food Restriction Counteracts Dexamethasone-Induced Downregulation of Genes Involved in Cholesterol Homeostasis in Rat Brain during Aging.Brain sciences · 2022Article
- Digging behavior discrimination test to probe burrowing and exploratory digging in male and female mice.Journal of neuroscience research · 2021Article
- A cross-species assessment of behavioral flexibility in compulsive disorders.Communications biology · 2021Article
- Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives.Frontiers in behavioral neuroscience · 2021Article
- A virtual issue highlighting animal studies of eating disorders as valuable tools for examining neurobiological underpinnings and treatment of eating disorders.The International journal of eating disorders · 2020Article
- Role of addiction and stress neurobiology on food intake and obesity.Biological psychology · 2018Review
- To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity.Frontiers in integrative neuroscience · 2018Article
- Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function.Nature communications · 2017Article
- Melanocortin-3 receptors expressed in Nkx2.1(+ve) neurons are sufficient for controlling appetitive responses to hypocaloric conditioning.Scientific reports · 2017Article
- A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice.Scientific reports · 2017Article
- Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line.PloS one · 2017Article
- Experimental Models of Maternal Obesity and Neuroendocrine Programming of Metabolic Disorders in Offspring.Frontiers in endocrinology · 2017Review
- Measuring discrimination- and reversal learning in mouse models within 4 days and without prior food deprivation.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Impact of external pneumatic compression target inflation pressure on transcriptome-wide RNA expression in skeletal muscle.Physiological reports · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFood restriction is known to enhance learning and motivation. The neural mechanisms underlying these responses likely involve alterations in gene expression in brain regions mediating the motivation to feed.
methodsAnalysis of gene expression profiles in male C57BL/6J mice using whole-genome microarrays was completed in the medial prefrontal cortex, nucleus accumbens, ventral tegmental area, and the hypothalamus following a 5-day food restriction. Quantitative polymerase chain reaction was used to validate these findings and determine the time course of expression changes. Plasma levels of the stress hormone corticosterone (CORT) were measured by enzyme-linked immunosorbent assay. Expression changes were measured in adrenalectomized animals that underwent food restriction, as well as in animals receiving daily injections of CORT. Progressive ratio responding for food, a measure of motivated behavior, was assessed after CORT treatment in restricted and fed animals.
resultsBrief food restriction results in an upregulation of peripheral stress responsive genes in the mammalian brain. Time-course analysis demonstrated rapid and persistent expression changes in all four brain regions under study. Administration of CORT to nonrestricted animals was sufficient to induce a subset of the genes, and alterations in gene expression after food restriction were dependent on intact adrenal glands. CORT can increase the motivation to work for food only in the restricted state.
conclusionsThese data demonstrate a central role for CORT in mediating both molecular and behavioral responses to food restriction. The stress hormone-induced alterations in gene expression described here may be relevant for both adaptive and pathological responses to stress.
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