ArticleGastroenterology2011
Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury.
Article in Gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.
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Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it, 329 citations in OpenAlex.
- The burden of HEV-related acute liver failure in Bangladesh, China and India: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Transfusion-associated hepatitis before the screening of blood for hepatitis risk factors.Transfusion · 2014Trial
- Atypical presentation of hepatitis E with extremely elevated bilirubin levels: a case report.Annals of medicine and surgery (2012) · 2025Article
- Chronic hepatitis E complicated by chylous ascites in an HIV-infected patient with previous disseminated MAC infection: a case report.ASM case reports · 2025Article
- Chemotherapy-induced febrile neutropenia followed by acute hepatitis E virus infection in rectal cancer patient with synchronous liver and lung metastasis: a case report.BMC infectious diseases · 2025Article
- Blood toxicogenomics reveals potential biomarkers for management of idiosyncratic drug-induced liver injury.Frontiers in genetics · 2025Article
- Viral etiologies of acute liver failure.World journal of virology · 2024Review
- Misdiagnosed Antibiotic-Induced Liver Injury: Unveiling Acute Hepatitis E in a 65-Year-Old Patient.The American journal of case reports · 2024Article
- Recent advances in the diagnosis of drug-induced liver injury.World journal of hepatology · 2024Review
- Hepatitis-E-induced cholestasis in a child: a case report.Annals of medicine and surgery (2012) · 2023Article
- The Diagnosis, Pathophysiology, and Treatment of Chronic Hepatitis E Virus Infection-A Condition Affecting Immunocompromised Patients.Microorganisms · 2023Review
- Is Hepatitis E Virus a Neglected or Emerging Pathogen in Egypt?Pathogens (Basel, Switzerland) · 2022Review
- Hepatitis E in immunocompromised individuals.World journal of hepatology · 2022Review
- Clinical characteristics and outcomes of drug-induced liver injury in Taiwan: With emphasis on the impact of chronic hepatitis B infection.Journal of the Chinese Medical Association : JCMA · 2022Article
- Prevalence of HEV infection in acute non-ABC hepatitis and prognostic role of extrahepatic manifestations.Le infezioni in medicina · 2022Article
- A Case of Hepatitis E Virus Infection: One of Differential Diagnosis of Liver Injury in Patients Undergoing Peritoneal Dialysis.International medical case reports journal · 2022Article
- Case report: Kinetics of human leukocyte antigen receptor HLA-DR during liver injury induced by potassium para-aminobenzoate as assessed for causality using the updated RUCAM.Frontiers in pharmacology · 2022Article
- Herbal and dietary supplement-induced liver injury in Taiwan: comparison with conventional drug-induced liver injury.Hepatology international · 2021Article
- Infections at the nexus of metabolic-associated fatty liver disease.Archives of toxicology · 2021Review
- Hepatitis E Virus Superinfection: an Underrecognized Trigger of Acute Hepatitis B Virus Flare.Cureus · 2021Article
61 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 9 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsThe diagnosis of drug-induced liver injury relies on exclusion of other causes, including viral hepatitis A, B, and C. Hepatitis E virus (HEV) infection has been proposed as another cause of suspected drug-induced liver disease. We assessed the frequency of HEV infection among patients with drug-induced liver injury in the United States.
methodsThe Drug-Induced Liver Injury Network (DILIN) is a prospective study of patients with suspected drug-induced liver injury; clinical information and biological samples are collected to investigate pathogenesis and disease progression. We analyzed serum samples, collected from patients enrolled in DILIN, for immunoglobulin (Ig) G and IgM against HEV; selected samples were tested for HEV RNA.
resultsAmong 318 patients with suspected drug-induced liver injury, 50 (16%) tested positive for anti-HEV IgG and 9 (3%) for anti-HEV IgM. The samples that contained anti-HEV IgM (collected 2 to 24 weeks after onset of symptoms) included 4 that tested positive for HEV RNA genotype 3. Samples from the 6-month follow-up visit were available from 4 patients; they were negative for anti-HEV IgM, but levels of anti-HEV IgG increased with time. Patients who had anti-HEV IgM were mostly older men (89%; mean age, 67 years), and 2 were human immunodeficiency virus positive. Clinical reassessment of the 9 patients with anti-HEV IgM indicated that acute hepatitis E was the most likely diagnosis for 7 and might be the primary diagnosis for 2.
conclusionsHEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced. Serologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.
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