Evidence map›Paper›PMID 21855383›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2011

Seroprevalence of antibodies to influenza A/H1N1/2009 among transmission risk groups after the second wave in Mexico, by a virus-free ELISA method.

Leticia Elizondo-Montemayor, Mario M Alvarez, Martín Hernández-Torre, Patricia A Ugalde-Casas, Lorena Lam-Franco, Humberto Bustamante-Careaga, Fernando Castilleja-Leal, Julio Contreras-Castillo, Héctor Moreno-Sánchez, Daniela Tamargo-Barrera and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Leticia Elizondo-MontemayorSchool of Medicine, Instituto Tecnológico y de Estudios Superiores de Monterrey, Av. Morones Prieto 3000 Pte. Col. Los Doctores, CP 64710, Monterrey, Nuevo León, Mexico. lelizond@itesm.mx
Mario M Alvarez
Martín Hernández-Torre
Patricia A Ugalde-Casas
Lorena Lam-Franco
Humberto Bustamante-Careaga
Fernando Castilleja-Leal
Julio Contreras-Castillo
Héctor Moreno-Sánchez
Daniela Tamargo-Barrera
Felipe López-Pacheco
Pamela J Freiden
Stacey Schultz-Cherry
Tecnológico de Monterrey · MXSt. Jude Children's Research Hospital · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
NCI NIH HHS CA21765NCI NIH HHS P30 CA021765NIAID NIH HHS HHSN266200700005C
6 · The paper itself

Abstract

objectiveNo serological studies have been performed in Mexico to assess the seroprevalence of influenza A/H1N1/2009 in groups of people according to the potential risk of transmission. The aim of this study was to determine the seroprevalence of antibodies against influenza A/H1N1/2009 in subjects in Mexico grouped by risk of transmission.

methodsTwo thousand two hundred and twenty-two subjects were categorized into one of five occupation groups according to the potential risk of transmission: (1) students, (2) teachers, (3) healthcare workers, (4) institutional home residents aged >60 years, and (5) general population. Seroprevalence by potential transmission group and by age grouped into decades was determined by a virus-free ELISA method based on the recombinant receptor-binding domain of the hemagglutinin of influenza A/H1N1/2009 virus as antigen (85% sensitivity; 95% specificity). The Wilson score, Chi-square test, and logistic regression models were used for the statistical analyses.

resultsSeroprevalence for students was 47.3%, for teachers was 33.9%, for older adults was 36.5%, and for the general population was 33.0%, however it was only 24.6% for healthcare workers (p=0.011). Of the students, 56.6% of those at middle school, 56.4% of those at high school, 52.7% of those at elementary school, and 31.1% of college students showed positive antibodies (p<0.001). Seroprevalence was 44.6% for college teachers, 31.6% for middle school teachers, and 29.8% for elementary school teachers, but was only 20.3% for high school teachers (p=0.002).

conclusionsThe student group was the group most affected by influenza A/H1N1/2009, while the healthcare worker group showed the lowest prevalence. Students represent a key target for preventive measures.

Indexed as

Antigens, ViralAdolescentAdultAgedAged, 80 and overAge FactorsAntibodies, ViralChildCross-Sectional StudiesDisease OutbreaksEnzyme-Linked Immunosorbent AssayFacultyFemaleHealth PersonnelHumansIncidenceAntibodies, ViralAntigens, Viral

Identifiers

PMID21855383
PMCPMC4041370
OpenAlexW1970943790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.