ReviewTrends in endocrinology and metabolism: TEM2011
Regulation of gonadotropin-releasing hormone neurons by glucose.
Review in Trends in endocrinology and metabolism: TEM, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Metabolic hormones are integral regulators of female reproductive health and function.Bioscience reports · 2024Review
- Heat Stress: A Serious Disruptor of the Reproductive Physiology of Dairy Cows.Animals : an open access journal from MDPI · 2023Review
- The Combination of a Diversified Intake of Carbohydrates and Fats and Supplementation of Vitamin D in a Diet Does Not Affect the Levels of Hormones (Testosterone, Estradiol, and Cortisol) in Men Practicing Strength Training for the Duration of 12 Weeks.International journal of environmental research and public health · 2020Article
- Article
- Short communication: reproductive response to concentrate supplementation of mixed-breed goats on rangeland.Tropical animal health and production · 2020Article
- Circadian Regulation of the Brain and Behavior: A Neuroendocrine Perspective.Current topics in behavioral neurosciences · 2019Article
- Emerging Concepts in Brain Glucose Metabolic Functions: From Glucose Sensing to How the Sweet Taste of Glucose Regulates Its Own Metabolism in Astrocytes and Neurons.Neuromolecular medicine · 2018Review
- Phoenixin: uncovering its receptor, signaling and functions.Acta pharmacologica Sinica · 2018Review
- Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice.Frontiers in immunology · 2018Article
- Estradiol-Dependent Stimulation and Suppression of Gonadotropin-Releasing Hormone Neuron Firing Activity by Corticotropin-Releasing Hormone in Female Mice.Endocrinology · 2018Article
- Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection.Frontiers in physiology · 2017Article
- Downregulation of coding transmembrane protein 35 gene inhibits cell proliferation, migration and cell cycle arrest in osteosarcoma cells.Experimental and therapeutic medicine · 2016Article
- Article
- The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1).Frontiers in neuroendocrinology · 2014Review
- Reproductive neuroendocrine dysfunction in polycystic ovary syndrome: insight from animal models.Frontiers in neuroendocrinology · 2014Review
- Article
- Nutrient-dependent/pheromone-controlled adaptive evolution: a model.Socioaffective neuroscience & psychology · 2013Review
- Negative effects of high glucose exposure in human gonadotropin-releasing hormone neurons.International journal of endocrinology · 2013Article
- Integrative control of energy balance and reproduction in females.ISRN veterinary science · 2012Article
- Sense and nonsense in metabolic control of reproduction.Frontiers in endocrinology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Reproduction is influenced by energy balance, but the physiological pathways mediating their relationship have not been fully elucidated. As the central regulators of fertility, gonadotropin-releasing hormone (GnRH) neurons integrate numerous physiological signals, including metabolic cues. Circulating glucose levels regulate GnRH release and might in part mediate the effects of negative energy balance on fertility. Existing evidence suggests that neural pathways originating in the hindbrain, as well as in the hypothalamic feeding nuclei, transmit information concerning glucose availability to GnRH neurons. Here we review recent evidence suggesting that GnRH neurons might directly sense changes in glucose availability by a mechanism involving AMP-activated protein kinase. These findings expand our understanding of how metabolic signaling in the brain regulates reproduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.