Evidence map›Paper›PMID 21855248›Full record

ArticleDiagnostic microbiology and infectious disease2011

Combination therapy with daptomycin, linezolid, and rifampin as treatment option for MRSA meningitis and bacteremia.

Theodoros Kelesidis, Romney Humphries, Kevin Ward, Michael A Lewinski, Otto O Yang

Open access · greenAbstract readCase Reports
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Daptomycin and linezolid for severe methicillin-resistantWorld journal of clinical cases · 2022
    Article
  8. Frontiers in microbiology · 2022
    Article
  9. Article
  10. Review
  11. Article
  12. Role of linezolid combination therapy for serious infections: review of the current evidence.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Review
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Theodoros KelesidisDivision of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. tkelesidis@mednet.ucla.edu
Romney Humphries
Kevin Ward
Michael A Lewinski
Otto O Yang
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881
6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) meningitis is associated with a high mortality rate. Treatment is challenging in patients with allergy to vancomycin. Herein, we describe a case of MRSA bacteremia secondary to medical device infection with MRSA that was complicated by MRSA meningitis. This case provides evidence for a possible role of combination therapy of daptomycin, linezolid, and rifampin in cases of MRSA meningitis and bacteremia.

Indexed as

AcetamidesAnti-Bacterial AgentsBacteremiaDaptomycinDrug Therapy, CombinationHumansLinezolidMaleMeningitis, BacterialMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMiddle AgedOxazolidinonesRifampinStaphylococcal InfectionsTreatment OutcomeAcetamidesAnti-Bacterial AgentsDaptomycinLinezolidOxazolidinonesRifampin

Identifiers

PMID21855248
PMCPMC8053445
OpenAlexW2024677412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.