Trial reportThe Journal of allergy and clinical immunology2011
Most nocturnal asthma symptoms occur outside of exacerbations and associate with morbidity.
Trial report in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- The effects of experimental sleep disruption on daytime performance among children with asthma living in urban environments.Sleep health · 2025Article
- The relationship between teen-reported nocturnal asthma symptoms and daily functioning.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Article
- Effects of Polycyclic Aromatic Hydrocarbons on Lung Function in Children with Asthma: A Mediation Analysis.International journal of environmental research and public health · 2022Article
- Physical activity, lung function, and sleep outcomes in urban children with asthma.Pediatric pulmonology · 2021Article
- Asthma and academic performance in urban children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- Sleep in young children with asthma and their parents.Journal of child health care : for professionals working with children in the hospital and community · 2017Article
- Allergic sensitization and objective measures of sleep in urban school-aged children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Article
- Asthma-related lung function, sleep quality, and sleep duration in urban children.Sleep health · 2017Article
- Daily global stress is associated with nocturnal asthma awakenings in school-age children.The Journal of allergy and clinical immunology · 2016Observational
- Sleep and allergic disease: a summary of the literature and future directions for research.The Journal of allergy and clinical immunology · 2012Review
- Sleep duration, sleep hygiene, and insomnia in adolescents with asthma.The journal of allergy and clinical immunology. In practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundAlthough nocturnal awakenings help categorize asthma severity and control, their clinical significance has not been thoroughly studied.
objectiveWe sought to determine the clinical consequences of nocturnal asthma symptoms requiring albuterol (NASRAs) in children with mild-to-moderate persistent asthma outside of periods when oral corticosteroids were used for worsening asthma symptoms.
methodsTwo hundred eighty-five children aged 6 to 14 years with mild-to-moderate persistent asthma were randomized to receive one of 3 controller regimens and completed daily symptom diaries for 48 weeks. Diary responses were analyzed for the frequency and consequences of NASRAs.
resultsNASRAs occurred in 72.2% of participants at least once, and in 24.3% of participants, they occurred 13 or more times. The majority (81.3%) of nocturnal symptoms occurred outside of exacerbation periods and were associated the next day with the following events: albuterol use (56.9% of days preceded by nocturnal symptoms vs 18.1% of days not preceded by nocturnal symptoms; relative risk [RR], 2.3; 95% CI, 2.2-2.4), school absence (5.0% vs 0.3%; RR, 10.6; 95% CI, 7.8-14.4), and doctor contact (3.7% vs 0.2%; RR, 8.8; 95% CI, 6.1-12.5). Similar findings were noted during exacerbation periods (RRs of 1.7 for albuterol use, 5.5 for school absence, and 4.9 for doctor contacts). Nocturnal symptoms did not predict the onset of exacerbations.
conclusionNocturnal symptoms requiring albuterol in children with mild-to-moderate persistent asthma receiving controller therapy occurred predominantly outside of exacerbation periods. Despite being poor predictors of exacerbations, they were associated with increases in albuterol use, school absences, and doctor contacts the day after nocturnal symptom occurrences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.