ArticleAtherosclerosis2011
Impaired CXCR4 expression and cell engraftment of bone marrow-derived cells from aged atherogenic mice.
Article in Atherosclerosis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis.The Journal of biological chemistry · 2013Trial
- Review
- Role of Endothelial Progenitor Cells in Frailty.International journal of molecular sciences · 2023Review
- Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus.Frontiers in cell and developmental biology · 2023Review
- The Role of CXC Chemokines in Cardiovascular Diseases.Frontiers in pharmacology · 2021Review
- Tissue-Specific Role of Macrophages in Noninfectious Inflammatory Disorders.Biomedicines · 2020Review
- Long-term repopulation of aged bone marrow stem cells using young Sca-1 cells promotes aged heart rejuvenation.Aging cell · 2019Article
- Review
- Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell TherapyInternational journal of molecular sciences · 2019Review
- Endothelial progenitor cells in age-related vascular remodeling.Cell transplantation · 2018Review
- Roles of Mesenchymal Stem Cells in Spinal Cord Injury.Stem cells international · 2017Review
- Ageing induced vascular smooth muscle cell senescence in atherosclerosis.The Journal of physiology · 2016Review
- Roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease.Journal of immunology research · 2014Review
- Regulation of atherogenesis by chemokines and chemokine receptors.Archivum immunologiae et therapiae experimentalis · 2013Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesReduced numbers and activity of circulating progenitor cells are associated with aging and have been linked with coronary artery disease. To determine the impact of aging and atherosclerotic disease on the chemotaxic activity of bone marrow derived cells (BMCs), we examined CXCR4 surface expression on BMCs from aged and atherosclerotic mice.
methodsCXCR4 expression and cellular mobility were compared between BMCs of young (6-week old) ApoE null mice (ApoE(-/-)) and aged ApoE(-/-) mice that had been fed with a high-fat, high-cholesterol diet for 6-months.
resultsAge and atherosclerosis correlated with significantly lower surface expression of CXCR4 that was less inducible by calcium. The impaired calcium response was associated with defective calcium influx and was partially recovered by treatment with the calcium ionophore ionomycin. ApoE(-/-) mice fed high fat diet for 6-months had defective CXCR4 expression and SDF-1 regulation that is equivalent to that of 24-month old wild type mice. BMCs from aged, atherogenic ApoE(-/-) mice also displayed defective homing to SDF-1, and the animals had lower serum and bone marrow levels of SDF-1.
conclusionEvolution of atherosclerosis in ApoE(-/-) mice is paralleled by progressive loss of mobility of BMCs with reductions of CXCR4 expression, and reduced levels of SDF-1 in both serum and bone marrow. These changes mute the homing capability of BMCs and may contribute to the progression of atherosclerosis in this model.
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Registered trials
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