ReviewJournal of immunological methods2011
Ex vivo purification and characterization of human invariant Natural Killer T cells.
Review in Journal of immunological methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Hepatocellular cancer-derived alpha fetoprotein uptake reduces CD1 molecules on monocyte-derived dendritic cells.Cellular immunology · 2019Article
- Subpopulations of natural killer-T-like cells before and after surgical treatment of laryngeal cancer.Central-European journal of immunology · 2017Article
- An Immunological Perspective on Neonatal Sepsis.Trends in molecular medicine · 2016Review
- Type 2 innate lymphoid cells: friends or foes-role in airway allergic inflammation and asthma.Journal of allergy · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Natural Killer T (NKT) cells have gained widespread attention among immunologists because of their distinct ability to regulate anti-tumor responses and to influence the outcome of infections or autoimmunity. Type I (also called invariant) NKT cells (iNKT) are best characterized mainly because of the availability of lipid antigen-loaded CD1d-tetramer detection reagents. Human iNKT cells present important phenotypic differences relative to their murine counterpart, restricting the extrapolation of findings from experimental murine models to human health and disease states. Particularly, the ontogeny and early life phenotype of iNKT cells largely differ between human and mice, indicating divergent functional properties between species. The high therapeutic potential offered by manipulation of iNKT cells in disease warrants a better understanding of human iNKT cell biology. Here, we discuss characteristics of human iNKT cells and present an efficient and rapid method for their ex vivo purification and characterization.
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Registered trials
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