ArticleExperimental eye research2011
Cellular and 3D optical coherence tomography assessment during the initiation and progression of retinal degeneration in the Ccl2/Cx3cr1-deficient mouse.
Article in Experimental eye research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Prospective study of common variants in CX3CR1 and risk of macular degeneration: pooled analysis from 5 long-term studies.JAMA ophthalmology · 2014Trial
- Sentinels or saboteurs, the Janus face of cochlear-resident macrophages in hearing loss: spatiotemporal distribution, pathophysiological functions, and translational potential.Journal of neuroinflammation · 2025Review
- Breakthroughs in diabetic retinopathy diagnosis and treatment using preclinical research models: current progress and future directions.Annals of medicine · 2025Review
- Melanin-Concentrating Hormone (MCH): Role in Mediating Reward-Motivated and Emotional Behavior and the Behavioral Disturbances Produced by Repeated Exposure to Reward Substances.International journal of molecular sciences · 2025Review
- Multiple Hub Genes as Diagnostic and Therapeutic Targets Inducing Inflammation and Angiogenesis in Retinopathy of Prematurity.International journal of general medicine · 2025Article
- Bisretinoids mediate light sensitivity resulting in photoreceptor cell degeneration in mice lacking the receptor tyrosine kinase Mer.The Journal of biological chemistry · 2018Article
- Hypothalamic CCL2/CCR2 Chemokine System: Role in Sexually Dimorphic Effects of Maternal Ethanol Exposure on Melanin-Concentrating Hormone and Behavior in Adolescent Offspring.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Nicotine accelerates diabetes-induced retinal changes.Current eye research · 2015Article
- Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival.Nature communications · 2015Article
- Article
- Fundus autofluorescence and photoreceptor cell rosettes in mouse models.Investigative ophthalmology & visual science · 2014Article
- Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Early degeneration of photoreceptor synapse in Ccl2/Cx3cr1-deficient mice on Crb1(rd8) background.Synapse (New York, N.Y.) · 2013Article
- Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Fundus autofluorescence findings in a mouse model of retinal detachment.Investigative ophthalmology & visual science · 2012Article
- Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration.Journal of cell science · 2012Article
- Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model.Journal of neuroinflammation · 2012Article
- Quantifying optical microangiography images obtained from a spectral domain optical coherence tomography system.International journal of biomedical imaging · 2012Article
- Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Retinal pathologies common to human eye diseases, including abnormal retinal pigment epithelial (RPE) cells, drusen-like accumulation, photoreceptor atrophy, and choroidal neovascularization, have been reported in the Ccl2/Cx3cr1-deficient mouse. The Ccl2 gene encodes the pro-inflammatory chemokine CCL2 (MCP-1), which is responsible for chemotactic recruitment of monocyte-derived macrophages to sites of inflammation. The Cx3cr1 gene encodes the fractalkine receptor, CX3CR1, and is required for accumulation of monocytes and microglia recruited via CCL2. Chemokine-mediated inflammation is implicated in retinal degenerative diseases such as diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, and uveoretinitis, and proper chemokine signaling from the RPE, Müller glia, and astrocytes is necessary to regulate leukocyte trafficking. Therefore, this mouse, possessing aberrant chemokine signaling coupled with retinal degenerative pathologies, presents an ideal opportunity to investigate the effect of altered signaling on retinal homeostasis and photoreceptor degeneration. Since this mouse is a recent development, more data covering the onset, location, and progression rate of pathologies is needed. In the present study we establish these parameters and show two photoreceptor cell death processes. Our observations of decreased glutamine synthetase and increased glial fibrillary acidic protein suggest that Müller cells respond very early within regions where lesions are forming. Finally, we suggest that retinal angiomatous proliferation contributes to pathological angiogenesis in this Ccl2/Cx3cr1-deficient mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.