ArticlePsychological medicine2012
Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results.
Article in Psychological medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Evaluating historical candidate genes for schizophrenia.Molecular psychiatry · 2015Pooled it
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- Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia.Scientific reports · 2021Article
- On the diagnostic and neurobiological origins of bipolar disorder.Translational psychiatry · 2020Review
- Neural anomalies during vigilance in schizophrenia: Diagnostic specificity and genetic associations.NeuroImage. Clinical · 2020Article
- A review on neuroimaging studies of genetic and environmental influences on early brain development.NeuroImage · 2019Review
- Izmir Mental Health Cohort for Gene-Environment Interaction in Psychosis (TürkSch): Assessment of the Extended and Transdiagnostic Psychosis Phenotype and Analysis of Attrition in a 6-Year Follow-Up of a Community-Based Sample.Frontiers in psychiatry · 2019Article
- Treating the "E" in "G × E": Trauma-Informed Approaches and Psychological Therapy Interventions in Psychosis.Frontiers in psychiatry · 2019Review
- Genetic influences on conduct disorder.Neuroscience and biobehavioral reviews · 2018Review
- No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes.Biological psychiatry · 2017Article
- ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.NeuroImage · 2017Review
- No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.PLoS genetics · 2016Article
- Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use.Journal of abnormal psychology · 2016Article
- Systems psychopharmacology: A network approach to developing novel therapies.World journal of psychiatry · 2016Review
- Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample.Behavior genetics · 2015Article
- Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCandidate gene studies have been a key approach to the genetics of schizophrenia (SCZ). However, the results of these studies are confusing and no genes have been unequivocally implicated. The hypothesis-driven candidate gene literature can be appraised by comparison with the results of genome-wide association studies (GWAS).
methodWe describe the characteristics of hypothesis-driven candidate gene studies from the SZGene database, and use pathway analysis to compare hypothesis-driven candidate genes with GWAS results from the International Schizophrenia Consortium (ISC).
resultsSZGene contained 732 autosomal genes evaluated in 1374 studies. These genes had poor statistical power to detect genetic effects typical for human diseases, assessed only 3.7% of genes in the genome, and had low marker densities per gene. Most genes were assessed once or twice (76.9%), providing minimal ability to evaluate consensus across studies. The ISC studies had 89% power to detect a genetic effect typical for common human diseases and assessed 79% of known autosomal common genetic variation. Pathway analyses did not reveal enrichment of smaller ISC p values in hypothesis-driven candidate genes, nor did a comprehensive evaluation of meta-hypotheses driving candidate gene selection (SCZ as a disease of the synapse or neurodevelopment). The most studied hypothesis-driven candidate genes (COMT, DRD3, DRD2, HTR2A, NRG1, BDNF, DTNBP1 and SLC6A4) had no notable ISC results.
conclusionsWe did not find support for the idea that the hypothesis-driven candidate genes studied in the literature are enriched for the common genetic variation involved in the etiology of SCZ. Larger samples are required to evaluate this conclusion definitively.
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