ArticleBMC complementary and alternative medicine2011
High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis.
Article in BMC complementary and alternative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Effects of Withania somnifera (Ashwagandha) on Hematological and Biochemical Markers, Hormonal Behavior, and Oxidant Response in Healthy Adults: A Systematic Review.Current nutrition reports · 2023Pooled it
- Safety and tolerability of Ashwagandha (Frontiers in nutrition · 2026Trial
- Exploring the efficacy and safety of a novel standardized ashwagandha (Journal of psychopharmacology (Oxford, England) · 2023Trial
- Safety of 12-Months Administration of Ashwagandha ( Withania somnifera ) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study.Phytotherapy research : PTR · 2026Observational
- Preliminary phytochemical profiling and in vitro antibacterial activity of Lycium edgeworthii (Solanaceae) leaf extract against multidrug-resistant bacterial pathogens.Scientific reports · 2026Article
- Cytotoxic Potential Evaluation of Innovative Pressurised Cyclic Solid-Liquid Extracts fromPlants (Basel, Switzerland) · 2026Article
- The Clinical Implications of Ashwagandha (Nutrients · 2026Review
- Medicinal Plants for Major Depressive Disorder.Brain sciences · 2026Review
- Ashwagandha: Optimizing the Extraction and Electrospun Nanofiber Production.Pharmaceutics · 2025Article
- Polyphenol-polysaccharide interactions: molecular mechanisms and potential applications in food systems - a comprehensive review.Food production, processing and nutrition · 2025Review
- The benefits of ashwagandha (Frontiers in nutrition · 2024Review
- Article
- Sub-acute toxicity of Ashwagandha (Toxicology reports · 2023Article
- Recent Advancements in Extraction Techniques of Ashwagandha (ACS omega · 2023Review
- Withania somnifera extracts induced attenuation of HIV-1: a mechanistic approach to restrict viral infection.Virology journal · 2023Article
- Protective impacts ofToxicology research · 2023Article
- Article
- Phytochemical Profiles and Biological Studies of Selected Botanical Dietary Supplements Used in the United States.Progress in the chemistry of organic natural products · 2023Article
- An updated review on phytochemistry and molecular targets ofFrontiers in pharmacology · 2023Review
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWithania somnifera is an important medicinal plant traditionally used in the treatment of many diseases. The present study was carried out to characterize the phenolic acids, flavonoids and 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activities in methanolic extracts of W. somnifera fruits, roots and leaves (WSFEt, WSREt and WSLEt).
methodsWSFEt, WSREt and WSLEt was prepared by using 80% aqueous methanol and total polyphenols, flavonoids as well as DPPH radical scavenging activities were determined by spectrophotometric methods and phenolic acid profiles were determined by HPLC methods.
resultsHigh concentrations of both phenolics and flavonoids were detected in all parts of the plant with the former ranging between 17.80 ± 5.80 and 32.58 ± 3.16 mg/g (dry weight) and the latter ranging between 15.49 ± 1.02 and 31.58 ± 5.07 mg/g. All of the three different plant parts showed strong DPPH radical scavenging activities (59.16 ± 1.20 to 91.84 ± 0.38%). Eight polyphenols (gallic, syringic, benzoic, p-coumaric and vanillic acids as well as catechin, kaempferol and naringenin) have been identified by HPLC in parts of the plant as well. Among all the polyphenols, catechin was detected in the highest concentration (13.01 ± 8.93 to 30.61 ± 11.41 mg/g).
conclusionThe results indicating that W. somnifera is a plant with strong therapeutic properties thus further supporting its traditional claims. All major parts of W. somnifera such as the roots, fruits and leaves provide potential benefits for human health because of its high content of polyphenols and antioxidant activities with the leaves containing the highest amounts of polyphenols specially catechin with strong antioxidant properties.
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