ArticleGenome biology2011
Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.
Article in Genome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 94 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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94 citing papers in PubMed, 212 citations in OpenAlex.
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- Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies.GeroScience · 2022Article
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- Threatened Species Initiative: Empowering conservation action using genomic resources.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genome assembly of the numbat (GigaByte (Hong Kong, China) · 2022Article
- Pros and cons for the evidence of adaptive non-shivering thermogenesis in marsupials.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Review
- Profile of Jennifer Marshall Graves.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Annotation of immune genes in the extinct thylacine (Thylacinus cynocephalus).Immunogenetics · 2021Article
- Contemporary and historical selection in Tasmanian devils (Proceedings. Biological sciences · 2021Article
- A reference genome for the critically endangered woylie,GigaByte (Hong Kong, China) · 2021Article
- Ancient viral integrations in marsupials: a potential antiviral defence.Virus evolution · 2021Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issuedPatel, Hardip R [added]
Authors and funding
104 authors at 13 institutions in 4 countries.
Funding
Abstract
backgroundWe present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced. The tammar has many unusual biological characteristics, including the longest period of embryonic diapause of any mammal, extremely synchronized seasonal breeding and prolonged and sophisticated lactation within a well-defined pouch. Like other marsupials, it gives birth to highly altricial young, and has a small number of very large chromosomes, making it a valuable model for genomics, reproduction and development.
resultsThe genome has been sequenced to 2 × coverage using Sanger sequencing, enhanced with additional next generation sequencing and the integration of extensive physical and linkage maps to build the genome assembly. We also sequenced the tammar transcriptome across many tissues and developmental time points. Our analyses of these data shed light on mammalian reproduction, development and genome evolution: there is innovation in reproductive and lactational genes, rapid evolution of germ cell genes, and incomplete, locus-specific X inactivation. We also observe novel retrotransposons and a highly rearranged major histocompatibility complex, with many class I genes located outside the complex. Novel microRNAs in the tammar HOX clusters uncover new potential mammalian HOX regulatory elements.
conclusionsAnalyses of these resources enhance our understanding of marsupial gene evolution, identify marsupial-specific conserved non-coding elements and critical genes across a range of biological systems, including reproduction, development and immunity, and provide new insight into marsupial and mammalian biology and genome evolution.
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