ArticleThe American journal of drug and alcohol abuse2011
Relation of study design to recruitment and retention in CTN trials.
Article in The American journal of drug and alcohol abuse, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Can a participant-referred 'study buddy' increase retention of rural people who use drugs in research? A multi-site, randomized trial.Addiction (Abingdon, England) · 2026Trial
- An evaluation of paid social media advertising and traditional advertising for addiction research recruitment.Drug and alcohol dependence · 2025Trial
- Optimizing Recruitment and Retention in Substance Use Disorder Research in Emergency Departments.The western journal of emergency medicine · 2023Trial
- Predictors of urine toxicology and other biologic specimen missingness in randomized trials of substance use disorders.Drug and alcohol dependence · 2024Article
- Article
- Article
- Identifying and responding to trial implementation challenges during multisite clinical trials.Journal of substance abuse treatment · 2020Article
- Attitudes and Preferences Toward a Hypothetical Trial of an Internet-Administered Psychological Intervention for Parents of Children Treated for Cancer: Web-Based Survey.JMIR mental health · 2018Article
- Factors Associated with Recruitment and Retention in Randomized Controlled Trials of Behavioral Interventions for Patients with Pediatric Type 1 Diabetes.Journal of clinical psychology in medical settings · 2016Article
- Site selection in community-based clinical trials for substance use disorders: strategies for effective site selection.The American journal of drug and alcohol abuse · 2011Article
- The design and analysis of multisite effectiveness trials: a decade of progress in the National Drug Abuse Clinical Trials Network.The American journal of drug and alcohol abuse · 2011Article
- Addiction treatment trials: how gender, race/ethnicity, and age relate to ongoing participation and retention in clinical trials.Substance abuse and rehabilitation · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundRecruitment and retention in randomized clinical trials are difficult in general and particularly so in trials of substance abuse treatments. Understanding trial design characteristics that could affect recruitment and retention rates would help in the design of future trials.
objectiveTo test whether any of the following factors are associated with recruitment or retention: type of intervention, type of therapy, duration of treatment, total duration of trial, number of treatment sessions, number of follow-up visits, number of primary assessments, timing of primary assessments, number of case report form (CRF) pages at baseline, and number of CRF pages for the entire trial.
methodsRecruitment and retention data from 24 Clinical Trials Network (CTN) trials conducted and completed between 2001 and 2010 were analyzed using single-factor analysis of variance and single-predictor regression methods to test their association with trial design characteristics.
resultsAlmost all of the analyses performed did not show statistically significant patterns between recruitment and retention rates and the trial design characteristics considered.
conclusionIn CTN trials, the relationship between assessment burden on participants and length of trial, on the one hand, and recruitment and retention, on the other, is not as strong and direct as expected. Other factors must impinge on the conduct of the trial to influence trial participation. SCIENTIFIC SIGNIFICANCE: Researchers may deem slightly more justifiable to permit inclusion of some of the design features that previously were assumed to have a strong, negative influence on recruitment and retention, and should consider other strategies that may have a stronger, more direct effect on trial participation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.