Trial reportThe American journal of drug and alcohol abuse2011
Some considerations for excess zeroes in substance abuse research.
Trial report in The American journal of drug and alcohol abuse, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- The Development of an Internet-Based Treatment for Problem Gamblers and Concerned Significant Others: A Pilot Randomized Controlled Trial.Journal of gambling studies · 2018Trial
- Modeling longitudinal drinking data in clinical trials: an application to the COMBINE study.Drug and alcohol dependence · 2013Trial
- Estimating marginal effects with zero-inflated models: A tutorial with the R package mzim.Behavior research methods · 2026Article
- Mapping prescription drug monitoring program data to self-report measures of non-medical prescription opioid use in community pharmacy settings.Research in social & administrative pharmacy : RSAP · 2023Article
- Studying dietary intake in daily life through multilevel two-part modelling: a novel analytical approach and its practical application.The international journal of behavioral nutrition and physical activity · 2021Article
- The role of negative emotional reactivity and neighborhood factors in predicting marijuana use during early adolescence.Journal of adolescence · 2020Article
- Intent-to-treat analysis of cluster randomized trials when clusters report unidentifiable outcome proportions.Clinical trials (London, England) · 2020Article
- Pilot trial investigating a brief behavioral economic intervention as an adjunctive treatment for alcohol use disorder.Journal of substance abuse treatment · 2020Article
- Applying the zero-inflated Poisson model with random effects to detect abnormal rises in school absenteeism indicating infectious diseases outbreak.Epidemiology and infection · 2018Article
- Ethnic disparities in children's oral health: findings from a population-based survey of grade 1 and 2 schoolchildren in Alberta, Canada.BMC oral health · 2018Article
- Deficits in Access to Reward Are Associated with College Student Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2016Article
- Premeditation moderates the relation between sensation seeking and risky substance use among young adults.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2015Article
- The design and analysis of multisite effectiveness trials: a decade of progress in the National Drug Abuse Clinical Trials Network.The American journal of drug and alcohol abuse · 2011Article
- From Mouth-level to Tooth-level DMFS: Conceptualizing a Theoretical Framework.Journal of dental, oral and craniofacial epidemiologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCount data collected in substance abuse research often come with an excess of "zeroes," which are typically handled using zero-inflated regression models. However, there is a need to consider the design aspects of those studies before using such a statistical model to ascertain the sources of zeroes.
objectivesWe sought to illustrate hurdle models as alternatives to zero-inflated models to validate a two-stage decision-making process in situations of "excess zeroes."
methodsWe use data from a study of 45 cocaine-dependent subjects where the primary scientific question was to evaluate whether study participation influences drug-seeking behavior. The outcome, "the frequency (count) of cocaine use days per week," is bounded (ranging from 0 to 7). We fit and compare binomial, Poisson, negative binomial, and the hurdle version of these models to study the effect of gender, age, time, and study participation on cocaine use.
resultsThe hurdle binomial model provides the best fit. Gender and time are not predictive of use. Higher odds of use versus no use are associated with age; however once use is experienced, odds of further use decrease with increase in age. Participation was associated with higher odds of no-cocaine use; once there is use, participation reduced the odds of further use.
conclusionAge and study participation are significantly predictive of cocaine-use behavior. SCIENTIFIC SIGNIFICANCE: The two-stage decision process as modeled by a hurdle binomial model (appropriate for bounded count data with excess zeroes) provides interesting insights into the study of covariate effects on count responses of substance use, when all enrolled subjects are believed to be "at-risk" of use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.