Trial reportThe American journal of drug and alcohol abuse2011
Zero-inflated and hurdle models of count data with extra zeros: examples from an HIV-risk reduction intervention trial.
Trial report in The American journal of drug and alcohol abuse, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 344 citations in OpenAlex.
- Trial
- Trial
- Pain, psychological flexibility, and continued substance use in a predominantly hispanic adult sample receiving methadone treatment for opioid use disorder.Drug and alcohol dependence · 2020Trial
- Medicine-related beliefs predict attribution of symptoms to a sham medicine: A prospective study.British journal of health psychology · 2018Trial
- Evaluation of Sexual Risk Behavior Among Study Participants in the TDF2 PrEP Study Among Heterosexual Adults in Botswana.Journal of acquired immune deficiency syndromes (1999) · 2016Trial
- The male factor: Outcomes from a cluster randomized field experiment with a couples-based HIV prevention intervention in a South African township.Drug and alcohol dependence · 2016Trial
- Peer Network Counseling with Urban Adolescents: A Randomized Controlled Trial with Moderate Substance Users.Journal of substance abuse treatment · 2015Trial
- Predictors and moderators of outcomes of HIV/STD sex risk reduction interventions in substance abuse treatment programs: a pooled analysis of two randomized controlled trials.Substance abuse treatment, prevention, and policy · 2014Trial
- Sexual behaviour of heterosexual men and women receiving antiretroviral pre-exposure prophylaxis for HIV prevention: a longitudinal analysis.The Lancet. Infectious diseases · 2013Trial
- Modeling longitudinal drinking data in clinical trials: an application to the COMBINE study.Drug and alcohol dependence · 2013Trial
- Combined prolonged exposure therapy and paroxetine for PTSD related to the World Trade Center attack: a randomized controlled trial.The American journal of psychiatry · 2012Trial
- Acute Mental Health Impacts and Mid-Term Symptom Trajectories Following Wildfire Exposure.International journal of environmental research and public health · 2026Article
- Digital media balance and mental health: effects of a school-based program.Child and adolescent psychiatry and mental health · 2026Article
- Estimating marginal effects with zero-inflated models: A tutorial with the R package mzim.Behavior research methods · 2026Article
- Article
- Enhanced modeling approaches for count data analysis with focus on substance use outcomes.Journal of behavioral medicine · 2026Article
- Variation in responses to temperature in admixed Populus genotypes predicts geographic shifts in regions where hybrids are favored.The New phytologist · 2026Article
- Mapping interpersonal-to-cognitive pathways with suicidal ideation: unforgiveness-based moderators within the interpersonal theory of suicide framework.Frontiers in psychology · 2026Article
- A process-oriented perspective on pre-service teachers' self-efficacy and their motivational messages: Using large language models to classify teachers' speech.The British journal of educational psychology · 2025Article
- Restrictive and permissive alcohol policies during the COVID-19 pandemic and their association with alcohol consumption in the United States.The International journal on drug policy · 2025Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn clinical trials of behavioral health interventions, outcome variables often take the form of counts, such as days using substances or episodes of unprotected sex. Classically, count data follow a Poisson distribution; however, in practice such data often display greater heterogeneity in the form of excess zeros (zero-inflation) or greater spread in the values (overdispersion) or both. Greater sample heterogeneity may be especially common in community-based effectiveness trials, where broad eligibility criteria are implemented to achieve a generalizable sample.
objectivesThis article reviews the characteristics of Poisson model and the related models that have been developed to handle overdispersion (negative binomial (NB) model) or zero-inflation (zero-inflated Poisson (ZIP) and Poisson hurdle (PH) models) or both (zero-inflated negative binomial (ZINB) and negative binomial hurdle (NBH) models).
methodsAll six models were used to model the effect of an HIV-risk reduction intervention on the count of unprotected sexual occasions (USOs), using data from a previously completed clinical trial among female patients (N = 515) participating in community-based substance abuse treatment (Tross et al. Effectiveness of HIV/AIDS sexual risk reduction groups for women in substance abuse treatment programs: Results of NIDA Clinical Trials Network Trial. J Acquir Immune Defic Syndr 2008; 48(5):581-589). Goodness of fit and the estimates of treatment effect derived from each model were compared.
resultsThe ZINB model provided the best fit, yielding a medium-sized effect of intervention. CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: This article illustrates the consequences of applying models with different distribution assumptions on the data. If a model used does not closely fit the shape of the data distribution, the estimate of the effect of the intervention may be biased, either over- or underestimating the intervention effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.