ArticleCellular and molecular life sciences : CMLS2012
MicroRNA-132 targets HB-EGF upon IgE-mediated activation in murine and human mast cells.
Article in Cellular and molecular life sciences : CMLS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Heparin-binding EGF-like growth factor via miR-126 controls tumor formation/growth and the proteolytic niche in murine models of colorectal and colitis-associated cancers.Cell death & disease · 2024Article
- Article
- The role of human mast cells in allergy and asthma.Bioengineered · 2022Review
- Transposable element-derived sequences in vertebrate development.Mobile DNA · 2021Review
- MicroRNA Involvement in Allergic and Non-Allergic Mast Cell Activation.International journal of molecular sciences · 2019Review
- No difference in human mast cells derived from peanut allergic versus non-allergic subjects.Immunity, inflammation and disease · 2018Article
- The Stress-Responding miR-132-3p Shows Evolutionarily Conserved Pathway Interactions.Cellular and molecular neurobiology · 2018Article
- Inhibition of airway inflammation in a cockroach allergen model of asthma by agonists of miRNA-33b.Scientific reports · 2017Article
- Antisense miR-132 blockade via the AChE-R splice variant mitigates cortical inflammation.Scientific reports · 2017Article
- Circulating miRNA in patients with non-alcoholic fatty liver disease and coronary artery disease.BMJ open gastroenterology · 2016Article
- MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.The Journal of clinical investigation · 2015Article
- Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer.Molecular immunology · 2015Review
- Global microRNA expression is essential for murine mast cell development in vivo.Experimental hematology · 2014Article
- Myeloid-derived microRNAs, miR-223, miR27a, and miR-652, are dominant players in myeloid regulation.BioMed research international · 2014Review
- Identification of microRNAs regulating the developmental pathways of bone marrow derived mast cells.PloS one · 2014Article
- Correlation of MicroRNA 132 Up-regulation with an Unfavorable Clinical Outcome in Patients with Primary Glioblastoma Multiforme Treated with Radiotherapy Plus Concomitant and Adjuvant Temozolomide Chemotherapy.Translational oncology · 2013Article
- Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases.The Journal of allergy and clinical immunology · 2013Review
- miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity.PloS one · 2013Article
- Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- miR-212/132 expression and functions: within and beyond the neuronal compartment.Nucleic acids research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs provide an additional layer in the regulation of gene expression acting as repressors with several targets at the posttranscriptional level. This study describes microRNA expression patterns during differentiation and activation of mast cells. The expression levels of 567 different mouse miRNAs were compared by microarray between c-Kit+ committed progenitors, mucosal mast cells, resting and IgE-crosslinked BMMCs in vitro. The strongest upregulation of miR-132 upon IgE-mediated activation was validated in human cord blood-derived mast cells as well. HB-EGF growth factor also upregulated upon activation and was ranked high by more prediction algorithms. Co-transfection of miR-132 mimicking precursor and the 3'UTR of human Hbegf-containing luciferase vector proves that the predicted binding site is functional. In line with this, neutralization of miR-132 by anti-miR inhibitor leads to sustained production of HB-EGF protein in activated mast cells. Our data provide a novel example for negative regulation of a growth factor by an upregulated miRNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.