ArticlePloS one2011
Evolution of cagA oncogene of Helicobacter pylori through recombination.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- Beyond Low Prevalence: Exploring Antibiotic Resistance and Virulence Profiles in Sri Lankan Helicobacter pylori with Comparative Genomics.Microorganisms · 2025Article
- Genomic differentiation within East AsianMicrobial genomics · 2022Article
- Characterization of East-Asian Helicobacter pylori encoding Western EPIYA-ABC CagA.Journal of microbiology (Seoul, Korea) · 2022Article
- Genome-wide association study of gastric cancer- and duodenal ulcer-derivedMicrobial genomics · 2021Article
- The endemic Helicobacter pylori population in Southern Vietnam has both South East Asian and European origins.Gut pathogens · 2021Article
- Tailor-Made Detection of Individual Phosphorylated and Non-Phosphorylated EPIYA-Motifs ofCancers · 2019Article
- Review
- Whole Genome Sequence and Phylogenetic Analysis ShowFrontiers in cellular and infection microbiology · 2017Article
- Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
- Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.BMC microbiology · 2016Article
- Genome-wide survey of codons under diversifying selection in a highly recombining bacterial species, Helicobacter pylori.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- Rare Helicobacter pylori Virulence Genotypes in Bhutan.Scientific reports · 2016Article
- Elevated levels of adaption in Helicobacter pylori genomes from Japan; a link to higher incidences of gastric cancer?Evolution, medicine, and public health · 2015Article
- A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions.PLoS pathogens · 2015Article
- The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated with peptic ulcer and gastric cancer in Mexican population.BMC gastroenterology · 2014Article
- Effect of Helicobacter pylori on gastric epithelial cells.World journal of gastroenterology · 2014Review
- Phospholipid binding residues of eukaryotic membrane-remodelling F-BAR domain proteins are conserved in Helicobacter pylori CagA.BMC research notes · 2014Article
- Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region.International journal of bacteriology · 2014Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori is a gastric pathogen that infects half the human population and causes gastritis, ulcers, and cancer. The cagA gene product is a major virulence factor associated with gastric cancer. It is injected into epithelial cells, undergoes phosphorylation by host cell kinases, and perturbs host signaling pathways. CagA is known for its geographical, structural, and functional diversity in the C-terminal half, where an EPIYA host-interacting motif is repeated. The Western version of CagA carries the EPIYA segment types A, B, and C, while the East Asian CagA carries types A, B, and D and shows higher virulence. Many structural variants such as duplications and deletions are reported. In this study, we gained insight into the relationships of CagA variants through various modes of recombination, by analyzing all known cagA variants at the DNA sequence level with the single nucleotide resolution. Processes that occurred were: (i) homologous recombination between DNA sequences for CagA multimerization (CM) sequence; (ii) recombination between DNA sequences for the EPIYA motif; and (iii) recombination between short similar DNA sequences. The left half of the EPIYA-D segment characteristic of East Asian CagA was derived from Western type EPIYA, with Amerind type EPIYA as the intermediate, through rearrangements of specific sequences within the gene. Adaptive amino acid changes were detected in the variable region as well as in the conserved region at sites to which no specific function has yet been assigned. Each showed a unique evolutionary distribution. These results clarify recombination-mediated routes of cagA evolution and provide a solid basis for a deeper understanding of its function in pathogenesis.
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