ArticlePloS one2011
Lack of low frequency variants masks patterns of non-neutral evolution following domestication.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Genetic diversity, population structure, and selection signature in Ethiopian sorghum [Sorghum bicolor L. (Moench)] germplasm.G3 (Bethesda, Md.) · 2021Article
- Benchmarking the performance of Pool-seq SNP callers using simulated and real sequencing data.Molecular ecology resources · 2021Article
- Transcriptional Regulation of Sorghum Stem Composition: Key Players Identified Through Co-expression Gene Network and Comparative Genomics Analyses.Frontiers in plant science · 2020Article
- Article
- Domestication and the storage starch biosynthesis pathway: signatures of selection from a whole sorghum genome sequencing strategy.Plant biotechnology journal · 2016Article
- Allelic variation at a single gene increases food value in a drought-tolerant staple cereal.Nature communications · 2013Article
- Genetic structure, linkage disequilibrium and signature of selection in Sorghum: lessons from physically anchored DArT markers.PloS one · 2012Article
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Authors and funding
6 authors.
Funding
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Abstract
Detecting artificial selection in the genome of domesticated species can not only shed light on human history but can also be beneficial to future breeding strategies. Evidence for selection has been documented in domesticated species including maize and rice, but few studies have to date detected signals of artificial selection in the Sorghum bicolor genome. Based on evidence that domesticated S. bicolor and its wild relatives show significant differences in endosperm structure and quality, we sequenced three candidate seed storage protein (kafirin) loci and three candidate starch biosynthesis loci to test whether these genes show non-neutral evolution resulting from the domestication process. We found strong evidence of non-neutral selection at the starch synthase IIa gene, while both starch branching enzyme I and the beta kafirin gene showed weaker evidence of non-neutral selection. We argue that the power to detect consistent signals of non-neutral selection in our dataset is confounded by the absence of low frequency variants at four of the six candidate genes. A future challenge in the detection of positive selection associated with domestication in sorghum is to develop models that can accommodate for skewed frequency spectrums.
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