ReviewNature reviews. Neuroscience2011
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine.
Review in Nature reviews. Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 727 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Intranasal Oxytocin and Vasopressin on Social Behavior and Decision Making
Potential Benefits of the Somatic Psychoeducational Intervention for Improving the Health and Wellness of Healthcare Providers
Who cites it
727 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,686 citations in OpenAlex.
- The neuropeptide in ischemic brain injury: insights, challenges, and horizon of targeted interventions.Journal of translational medicine · 2026Pooled it
- Music's context-dependent influence on oxytocin, social bonding, and emotion regulation: a systematic review.Frontiers in cognition · 2025Pooled it
- miRNAs as biomarkers of autism spectrum disorder: a systematic review and meta-analysis.European child & adolescent psychiatry · 2024Pooled it
- Vasopressin in vasoplegic shock in surgical patients: systematic review and meta-analysis.Acta cirurgica brasileira · 2023Pooled it
- A Call for Drug Therapies for the Treatment of Social Behavior Disorders in Dementia: Systematic Review of Evidence and State of the Art.International journal of molecular sciences · 2022Pooled it
- Genetic Variants Associated With Resilience in Human and Animal Studies.Frontiers in psychiatry · 2022Pooled it
- Oxytocin and Oxytocin Receptor Gene Regulation in Williams Syndrome: A Systematic Review.The Yale journal of biology and medicine · 2021Pooled it
- Intranasal Oxytocin for Negative Symptoms of Schizophrenia: Systematic Review, Meta-Analysis, and Dose-Response Meta-Analysis of Randomized Controlled Trials.The international journal of neuropsychopharmacology · 2021Pooled it
- Bone turnover in arginine vasopressin deficiency: a comparative study with primary polydipsia and healthy controls.The Journal of clinical endocrinology and metabolism · 2026Trial
- Oxytocin Effects on Food Stimulus Processing and Food Intake in Females With or Without Binge Eating Disorder.The International journal of eating disorders · 2026Trial
- Vasopressin and angiotensin II pathways differentially modulate human fear response dynamics to looming threats.PLoS biology · 2026Trial
- Heartfulness meditation alters neuroendocrine profiles: A randomized controlled trial on hormones of stress and well-being.Medicine · 2025Trial
- Intranasal oxytocin modulates brain activity during emotional processing in children with treatment resistant conduct problems.Scientific reports · 2025Trial
- Maternal care is associated with neural and behavioral effects of oxytocin administration during empathic accuracy in schizophrenia and controls.Psychoneuroendocrinology · 2025Trial
- Effects of four-week intranasal oxytocin administration on large-scale brain networks in older adults.Neuropharmacology · 2024Trial
- Oxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame.Molecular psychiatry · 2024Trial
- Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin.Molecular psychiatry · 2024Trial
- Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms.The international journal of neuropsychopharmacology · 2022Trial
667 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are evolutionarily highly conserved mediators in the regulation of complex social cognition and behaviour. Recent studies have investigated the effects of OXT and AVP on human social interaction, the genetic mechanisms of inter-individual variation in social neuropeptide signalling and the actions of OXT and AVP in the human brain as revealed by neuroimaging. These data have advanced our understanding of the mechanisms by which these neuropeptides contribute to human social behaviour. OXT and AVP are emerging as targets for novel treatment approaches--particularly in synergistic combination with psychotherapy--for mental disorders characterized by social dysfunction, such as autism, social anxiety disorder, borderline personality disorder and schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.