Evidence map›Paper›PMID 21852677›Full record

ArticleDiabetes care2011

Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K.

Caroline A Abbott, Rayaz A Malik, Ernest R E van Ross, Jai Kulkarni, Andrew J M Boulton

3 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 397 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
397citing papers in PubMed, 12 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04217005 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Enhancing Functional and Cognitive Performances in People With Amputation and Peripheral Neuropathy Through the Restoration of Sensory Feedback in Real World and Virtual Reality Environments

TypeinterventionalSponsorETH ZurichRan2019 to 2026Enrolled20ConditionsLower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Diabetic Peripheral NeuropathyArmsSensory Feedback
NCT04306289 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effects of Transcranial Direct Current Stimulation (tDCS) on Pain Associated With Diabetic Neuropathy

TypeinterventionalSponsorUniversity of Rome Tor VergataRan2020 to 2022Enrolled20ConditionsDiabetic Neuropathies, Chronic PainArmstranscranial direct current stimulation
NCT04943614 nacompletednot on this mapstarted 2020, after this paper: background citation

Effect of BIODEX Balance System Training on Balance in Type II-diabetic Neuropathy.

TypeinterventionalSponsorRiphah International UniversityRan2020 to 2021Enrolled88ConditionsDiabetic NeuropathiesArmsBiodex balance system, conventional exercises
3 · Its place in the literature

Who cites it

397 citing papers in PubMed, 12 syntheses or guidelines pooled it, 845 citations in OpenAlex.

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337 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Caroline A AbbottDivision of Cardiovascular Medicine, Core Technology Facility, University of Manchester, Manchester, UK. caroline.abbott@manchester.ac.uk
Rayaz A Malik
Ernest R E van Ross
Jai Kulkarni
Andrew J M Boulton
Withington Community Hospital · GB

Funding

Department of Health
6 · The paper itself

Abstract

objectiveTo assess, in the general diabetic population, 1) the prevalence of painful neuropathic symptoms; 2) the relationship between symptoms and clinical severity of neuropathy; and 3) the role of diabetes type, sex, and ethnicity in painful neuropathy. RESEARCH DESIGN AND

methodsObservational study of a large cohort of diabetic patients receiving community-based health care in northwest England (n = 15,692). Painful diabetic neuropathy (PDN) was assessed using neuropathy symptom score (NSS) and neuropathy disability score (NDS).

resultsPrevalence of painful symptoms (NSS ≥5) and PDN (NSS ≥5 and NDS ≥3) was 34 and 21%, respectively. Painful symptoms occurred in 26% of patients without neuropathy (NDS ≤2) and 60% of patients with severe neuropathy (NDS >8). Adjusted risk of painful neuropathic symptoms in type 2 diabetes was double that of type 1 diabetes (odds ratio [OR] = 2.1 [95% CI 1.7-2.4], P < 0.001) and not affected by severity of neuropathy, insulin use, foot deformities, smoking, or alcohol. Women had 50% increased adjusted risk of painful symptoms compared with men (OR = 1.5 [1.4-1.6], P < 0.0001). Despite less neuropathy in South Asians (14%) than Europeans (22%) and African Caribbeans (21%) (P < 0.0001), painful symptoms were greater in South Asians (38 vs. 34 vs. 32%, P < 0.0001). South Asians without neuropathy maintained a 50% increased risk of painful neuropathy symptoms compared with other ethnic groups (P < 0.0001).

conclusionsOne-third of all community-based diabetic patients have painful neuropathy symptoms, regardless of their neuropathic deficit. PDN was more prevalent in patients with type 2 diabetes, women, and people of South Asian origin. This highlights a significant morbidity due to painful neuropathy and identifies key groups who warrant screening for PDN.

Indexed as

Administration, OralAdultAgedAge DistributionDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NeuropathiesFemaleHumansHypoglycemic AgentsMaleMiddle AgedSex FactorsUnited KingdomHypoglycemic Agents

Identifiers

PMID21852677
PMCPMC3177727
OpenAlexW2162902338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.