ArticleScience (New York, N.Y.)2011
Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number.
Article in Science (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of innate immunity on malaria parasite infection dynamics in rodent models.Frontiers in immunology · 2023Pooled it
- Malaria parasites can optimize transmission investment by sensing two within-host cues.PLoS biology · 2025Article
- Combining in vivo and in vitro approaches to better understand host-pathogen nutritional interactions.The Journal of animal ecology · 2025Article
- Dose-dependent interaction of parasites with tiers of host defense predicts "wormholes" that prolong infection at intermediate inoculum sizes.PLoS computational biology · 2024Article
- The impact of sterility-mortality tolerance and recovery-transmission trade-offs on host-parasite coevolution.Proceedings. Biological sciences · 2024Article
- Review
- Liver-stage fate determination inFrontiers in microbiology · 2022Article
- Article
- Differential drivers of intraspecific and interspecific competition during malaria-helminth co-infection.Parasitology · 2021Article
- Immune selection suppresses the emergence of drug resistance in malaria parasites but facilitates its spread.PLoS computational biology · 2021Article
- Disentangling the dynamical underpinnings of differences in SARS-CoV-2 pathology using within-host ecological models.PLoS pathogens · 2020Review
- Uncovering drivers of dose-dependence and individual variation in malaria infection outcomes.PLoS computational biology · 2020Article
- Simulation modelling for immunologists.Nature reviews. Immunology · 2020Review
- Effect of drug dose and timing of treatment on the emergence of drug resistanceEvolution, medicine, and public health · 2020Article
- The contribution of host cell-directed vs. parasite-directed immunity to the disease and dynamics of malaria infections.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Phenotypic plasticity in reproductive effort: malaria parasites respond to resource availability.Proceedings. Biological sciences · 2017Article
- A nutrient mediates intraspecific competition between rodent malaria parasitesProceedings. Biological sciences · 2017Article
- Host-mediated impairment of parasite maturation during blood-stageProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Facilitation through altered resource availability in a mixed-species rodent malaria infection.Ecology letters · 2016Article
- Predicting optimal transmission investment in malaria parasites.Evolution; international journal of organic evolution · 2016Article
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8 authors.
Funding
Abstract
Immune clearance and resource limitation (via red blood cell depletion) shape the peaks and troughs of malaria parasitemia, which in turn affect disease severity and transmission. Quantitatively partitioning the relative roles of these effects through time is challenging. Using data from rodent malaria, we estimated the effective propagation number, which reflects the relative importance of contrasting within-host control mechanisms through time and is sensitive to the inoculating parasite dose. Our analysis showed that the capacity of innate responses to restrict initial parasite growth saturates with parasite dose and that experimentally enhanced innate immunity can affect parasite density indirectly via resource depletion. Such a statistical approach offers a tool to improve targeting of drugs or vaccines for human therapy by revealing the dynamics and interactions of within-host regulatory mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.