Evidence map›Paper›PMID 21852452›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2011

JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals.

Raphael P Viscidi, Nina Khanna, Chen S Tan, Xiuhung Li, Lisa Jacobson, David B Clifford, Avindra Nath, Joseph B Margolick, Keerti V Shah, Hans H Hirsch and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 55 citations in OpenAlex.

  1. Trial
  2. JC Polyomavirus Infection: A Narrative Review.Infectious diseases and therapy · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Immune reconstitution after allogeneic hematopoietic stem cell transplantation is associated with selective control of JC virus reactivation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2014
    Article
  17. Article
  18. Article
  19. Multiplex qPCR assay for ultra sensitive detection of JCV DNA with simultaneous identification of genotypes that discriminates non-virulent from virulent variants.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2013
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Raphael P ViscidiDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. rviscid1@jhmi.edu
Nina Khanna
Chen S Tan
Xiuhung Li
Lisa Jacobson
David B Clifford
Avindra Nath
Joseph B Margolick
Keerti V Shah
Hans H Hirsch
Igor J Koralnik
Johns Hopkins University · USBeth Israel Deaconess Medical Center · USUniversity of Basel · CHJohns Hopkins Medicine · USWashington University in St. Louis · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
NATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Leah Helane Rubin · 2006 to 2026
$33.2M
METHODOLOGICAL EXPERTISE IN INTREPRETING MACS DATAU01AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JACOBSON, LISA P · 1993 to 2011
$26.9M
INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Role of Inflammation in Progressive Multifocal LeukoencephalopathyR01NS047029 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2004 to 2018
$6.4M
CELLULAR IMMUNITY TO JC VIRUS IN AIDS ASSOCIATED PMLR01NS041198 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KORALNIK, IGOR J. · 2001 to 2009
$3.3M
JC Virus Primary Infection, Latency, and ReactivationK08NS064215 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TAN, CHEN SABRINA · 2009 to 2013
$865k
NCRR NIH HHS 5-MO1-RR-00052NCRR NIH HHS M01 RR000052NIAID NIH HHS P30 AI060354NIAID NIH HHS T32 AI007061NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS U01 AI035043NIAID NIH HHS UO1-AI-35039NIAID NIH HHS UO1-AI-35040NIAID NIH HHS UO1-AI-35041NIAID NIH HHS UO1-AI-35042NIAID NIH HHS UO1-AI-35043NIMH NIH HHS 5P30MH075673NIMH NIH HHS P30 MH075673NINDS NIH HHS K08 NS064215NINDS NIH HHS K24 NS 060950NINDS NIH HHS K24 NS060950NINDS NIH HHS NS 047029NINDS NIH HHS R01 NS 041198NINDS NIH HHS R01 NS041198NINDS NIH HHS R01 NS047029NINDS NIH HHS U01 NS322228
6 · The paper itself

Abstract

We examined whether prediagnostic John Cunningham virus (JCV) antibodies and viremia are predictors of progressive multifocal leukoencephalopathy (PML) in 83 PML cases and 240 human immunodeficiency virus (HIV) disease-matched controls. JCV viremia was not predictive of PML, but some patients showed higher anti-JCV immunoglobulin G (IgG) responses 6 months prior to diagnosis.

Indexed as

ViremiaAdultAntibodies, ViralFemaleHIV-1HIV InfectionsHumansImmunoglobulin GJC VirusLeukoencephalopathy, Progressive MultifocalMaleMiddle AgedPredictive Value of TestsAntibodies, ViralImmunoglobulin G

Identifiers

PMID21852452
PMCPMC3166351
OpenAlexW2159032161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.