ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2011
Menin and JunD regulate gastrin gene expression through proximal DNA elements.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Histone H1 variants regulate neurodevelopmental transcriptional programs in autism with 16p11.2 deletion.Genome biology · 2026Article
- Extracellular signalling regulates gastrin transcription through site-specific phosphorylation and nuclear redistribution of Menin.bioRxiv : the preprint server for biology · 2026Article
- Menin in Cancer.Genes · 2024Review
- Clinically Defined Mutations inCancer research communications · 2023Article
- Gastrin: From Physiology to Gastrointestinal Malignancies.Function (Oxford, England) · 2022Review
- Expression profiling of Tas2r genes reveals a complex pattern along the mouse GI tract and the presence of Tas2r131 in a subset of intestinal Paneth cells.Cellular and molecular life sciences : CMLS · 2018Article
- Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.Gastroenterology · 2017Article
- Modulation by miR-29b of intestinal epithelium homoeostasis through the repression of menin translation.The Biochemical journal · 2015Article
- Menin directly represses Gli1 expression independent of canonical Hedgehog signaling.Molecular cancer research : MCR · 2013Article
- Management of gastric carcinoids (neuroendocrine neoplasms).Current gastroenterology reports · 2012Article
- Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mutations in the MEN1 gene correlate with multiple endocrine neoplasia I (MEN1). Gastrinomas are the most malignant of the neuroendocrine tumors associated with MEN1. Because menin and JunD proteins interact, we examined whether JunD binds to and regulates the gastrin gene promoter. Both menin and JunD are ubiquitous nuclear proteins that we showed colocalize in the gastrin-expressing G cells of the mouse antrum. Transfection with a JunD expression vector alone induced endogenous gastrin mRNA in AGS human gastric cells, and the induction was blocked by menin overexpression. We mapped repression by menin to both a nonconsensus AP-1 site and proximal GC-rich elements within the human gastrin promoter. Chromatin immunoprecipitation assays, EMSAs, and DNA affinity precipitation assays documented that JunD and Sp1 proteins bind these two elements and are both targets for menin regulation. Consistent with menin forming a complex with histone deacetylases, we found that repression of gastrin gene expression by menin was reversed by trichostatin A. In conclusion, proximal DNA elements within the human gastrin gene promoter mediate interactions between JunD, which induces gastrin gene expression and menin, which suppresses JunD-mediated activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.