Evidence map›Paper›PMID 21852311›Full record

ArticleEuropean journal of heart failure2011

Potential value of automated daily screening of cardiac resynchronization therapy defibrillator diagnostics for prediction of major cardiovascular events: results from Home-CARE (Home Monitoring in Cardiac Resynchronization Therapy) study.

Stefan Sack, Christian Michael Wende, Herbert Nägele, Amos Katz, Wolfgang Rudolf Bauer, Craig Scott Barr, Klaus Malinowski, Harald Schwacke, Francisco Leyva, Jochen Proff and 2 more

2 registry-linked trialsOpen access · hybridAbstract readEvaluation Study
In one paragraph

Article in European journal of heart failure, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00376116 completednot on this map

Home CARE - Home Monitoring in CArdiac REsynchronisation Therapy

TypeobservationalSponsorBiotronik SE & Co. KGRan2005 to 2008Enrolled513ConditionsHeart Failure, CongestiveArmsCardiac resynchronisation therapy, Implantable cardioverter-defibrillator
NCT04455828 withdrawnnot on this mapstarted 2021, after this paper: background citation

Wearable Remote Monitoring of Heart Rate and Respiratory Rate for Heart Failure

TypeobservationalSponsorMilton S. Hershey Medical CenterRan2021 to 2022Enrolled0ConditionsHeart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection FractionArmsWHOOP strap 3.0
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 56 citations in OpenAlex.

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  13. Effectiveness of remote monitoring of CIEDs in detection and treatment of clinical and device-related cardiovascular events in daily practice: the HomeGuide Registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2013
    Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 5 countries.

Stefan SackCardiology Department, Universitätsklinikum Essen, Essen, Germany. stefan.sack@klinikum-muenchen.de
Christian Michael Wende
Herbert Nägele
Amos Katz
Wolfgang Rudolf Bauer
Craig Scott Barr
Klaus Malinowski
Harald Schwacke
Francisco Leyva
Jochen Proff
Sergey Berdyshev
Vincent Paul
Biotronik (Germany) · DEAsklepios Klinik Altona · DEBarzilai Medical Center · ILEssen University Hospital · DEEuropean Neuroendocrine Tumor Society · DEGood Hope Hospital · GBHelios Vogtland Klinikum Plauen · DEKrankenhaus Reinbek - Startseite · DERussells Hall Hospital · GBSt. Elisabeth Hospital · CWSt Peter's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate whether diagnostic data from implanted cardiac resynchronization therapy defibrillators (CRT-Ds) retrieved automatically at 24 h intervals via a Home Monitoring function can enable dynamic prediction of cardiovascular hospitalization and death. METHODS AND

resultsThree hundred and seventy-seven heart failure patients received CRT-Ds with Home Monitoring option. Data on all deaths and hospitalizations due to cardiovascular reasons and Home Monitoring data were collected prospectively during 1-year follow-up to develop a predictive algorithm with a predefined specificity of 99.5%. Seven parameters were included in the algorithm: mean heart rate over 24 h, heart rate at rest, patient activity, frequency of ventricular extrasystoles, atrial-atrial intervals (heart rate variability), right ventricular pacing impedance, and painless shock impedance. The algorithm was developed using a 25-day monitoring window ending 3 days before hospitalization or death. While the retrospective sensitivities of the individual parameters ranged from 23.6 to 50.0%, the combination of all parameters was 65.4% sensitive in detecting cardiovascular hospitalizations and deaths with 99.5% specificity (corresponding to 1.83 false-positive detections per patient-year of follow-up). The estimated relative risk of an event was 7.15-fold higher after a positive predictor finding than after a negative predictor finding.

conclusionWe developed an automated algorithm for dynamic prediction of cardiovascular events in patients treated with CRT-D devices capable of daily transmission of their diagnostic data via Home Monitoring. This tool may increase patients' quality of life and reduce morbidity, mortality, and health economic burden, it now warrants prospective studies. ClinicalTrials.gov  NCT00376116.

Indexed as

Cardiac Resynchronization TherapyDefibrillators, ImplantableMonitoring, AmbulatoryAgedFemaleGermanyHeart FailureHome Care ServicesHospitalizationHumansMaleMyocardial InfarctionPredictive Value of TestsSensitivity and Specificity

Identifiers

PMID21852311
PMCPMC3157971
OpenAlexW1993023246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.