ArticleJournal of bacteriology1990
Isolation and characterization of Candida albicans morphological mutants derepressed for the formation of filamentous hypha-type structures.
Article in Journal of bacteriology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Died or Not Dyed: Assessment of Viability and Vitality Dyes on Planktonic Cells and Biofilms fromJournal of fungi (Basel, Switzerland) · 2024Article
- Antifungal Activity of the Biphosphinic Cyclopalladate C7a againstFrontiers in microbiology · 2017Article
- Characterization of Candida albicans colony morphological mutants and their hybrids by means of RAPD-PCR, isoenzyme analysis and pathogenicity analysis.Folia microbiologica · 2004Article
- Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans.Molecular biology of the cell · 1997Article
- HOY1, a homeo gene required for hyphal formation in Yarrowia lipolytica.Molecular and cellular biology · 1997Article
- PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis.Molecular and cellular biology · 1995Article
- Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans.Infection and immunity · 1993Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several Candida albicans morphological mutants were obtained by a procedure based on a combined treatment with nitrous acid plus UV irradiation and a double-enrichment step to increase the proportion of mutants growing as long filamentous structures. Altered cell morphogenesis in these mutants correlated with an altered colonial phenotype. Two of these mutants, C. albicans NEL102 and NEL103, were selected and characterized. Mutant blastoconidia initiated budding but eventually gave rise to filamentous hypha-type formations. These filaments were long and septate, and they branched very regularly at positions near septa. Calcofluor white (which is known to bind chitin-rich areas) stained septa, branching zones, and filament tips very intensely, as observed under the fluorescence microscope. Wild-type hybrids were obtained by fusing protoplasts of strain NEL102 with B14, another morphological mutant previously described as being permanently pseudomycelial, indicating that genetic determinants responsible for the two altered phenotypes are different. The mutants characterized in this work seemed to sequentially express the morphogenic characteristics of C. albicans, from blastoconidia to hyphae, in the absence of any inducer. Further characterization of these strains could be relevant to gain understanding of the genetic control of dimorphism in this species.
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