ArticleJournal of neuroendocrinology2011
Prolactin induces a hyperpolarising current in rat paraventricular oxytocinergic neurones.
Article in Journal of neuroendocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Abscisic acid regulates maternal behavior in rats via PPARγ receptors and hypothalamic oxytocin signaling.Iranian journal of veterinary research · 2025Article
- Seasonality of prolactin in birds and mammals.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2022Review
- The Prolactin Family of Hormones as Regulators of Maternal Mood and Behavior.Frontiers in global women's health · 2021Review
- Effects ofInternational journal of veterinary science and medicine · 2019Article
- Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward.Neuroscience and biobehavioral reviews · 2017Review
- Prolactin regulation of oxytocin neurone activity in pregnancy and lactation.The Journal of physiology · 2017Article
- Prolactin receptor in regulation of neuronal excitability and channels.Channels (Austin, Tex.) · 2014Review
- Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.Journal of neuroendocrinology · 2013Review
- Oxytocin: an emerging regulator of prolactin secretion in the female rat.Journal of neuroendocrinology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Prolactin and oxytocin are important reproductive hormones implicated in several common adaptive functions during pregnancy, pseudopregnancy and lactation. Recently, extracellular recordings of supraoptic neurones have shown that prolactin may modulate the electrical activity of oxytocinergic neurones. However, no study has been conducted aiming to establish whether prolactin directly influences this activity in oxytocinergic paraventricular neurones. In the present study, we addressed this question by studying the effects of prolactin on the electrical activity and voltage-current relationship of identified paraventricular neurones in rat brain slices. Whole-cell recordings were obtained and neurones were classified on the basis of their morphological and electrophysiological fingerprint (i.e. magnocellular or parvicellular) and neuropeptide phenotype (i.e. oxytocinergic or non-oxytocinergic). We report that prolactin elicited a hyperpolarising current in 37% of the neurones in this nucleus, of which the majority (67%) were identified as putative magnocellular oxytocin neurones and the reminder (33%) were regarded as oxytocin-negative, parvicellular neuroendocrine neurones. Our results suggest that, in addition to the well-established negative feedback loop between prolactin-secreting lactotrophs and dopaminergic neurones in the arcuate nucleus, an inhibitory feedback loop also exists between lactotrophs and oxytocinergic paraventricular neurones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.