ReviewCritical reviews in biochemistry and molecular biology2011
Lipotoxicity and cardiac dysfunction in mammals and Drosophila.
Review in Critical reviews in biochemistry and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Lipidomics Reveals Myocardial Lipid Composition in a Murine Model of Insulin Resistance Induced by a High-Fat Diet.International journal of molecular sciences · 2024Article
- Lipotoxicity, ER Stress, and Cardiovascular Disease: Current Understanding and Future Directions.Cardiovascular & hematological agents in medicinal chemistry · 2024Review
- Reducing ether lipids improves Drosophila overnutrition-associated pathophysiology phenotypes via a switch from lipid storage to beta-oxidation.Scientific reports · 2022Article
- Profile of crosstalk between glucose and lipid metabolic disturbance and diabetic cardiomyopathy: Inflammation and oxidative stress.Frontiers in endocrinology · 2022Review
- Effects of Drosophila melanogaster regular exercise and apolipoprotein B knockdown on abnormal heart rhythm induced by a high-fat diet.PloS one · 2022Article
- Loss of Stearoyl-CoA desaturase 1 leads to cardiac dysfunction and lipotoxicity.The Journal of experimental biology · 2021Article
- Exercise-Training Regulates Apolipoprotein B inFrontiers in physiology · 2021Article
- Tissue-specific analysis of lipid species inJournal of lipid research · 2020Article
- Rosiglitazone ameliorates palmitic acid-induced cytotoxicity in TM4 Sertoli cells.Reproductive biology and endocrinology : RB&E · 2018Article
- Profile of cardiac lipid metabolism in STZ-induced diabetic mice.Lipids in health and disease · 2018Article
- Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy.Cell reports · 2018Article
- TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance.Scientific reports · 2017Article
- Review
- Gaining Insights into Diabetic Cardiomyopathy from Drosophila.Trends in endocrinology and metabolism: TEM · 2015Review
- Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptin.American journal of physiology. Renal physiology · 2015Article
- Obesity-associated cardiac dysfunction in starvation-selected Drosophila melanogaster.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Time-restricted feeding attenuates age-related cardiac decline in Drosophila.Science (New York, N.Y.) · 2015Article
- Methods for studying metabolism in Drosophila.Methods (San Diego, Calif.) · 2014Review
- Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster.Molecular metabolism · 2014Article
- High carbohydrate-low protein consumption maximizes Drosophila lifespan.Experimental gerontology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The lipotoxic effects of obesity are important contributing factors in cancer, diabetes, and cardiovascular disease (CVD), but the genetic mechanisms, by which lipotoxicity influences the initiation and progression of CVD are poorly understood. Hearts, of obese and diabetic individuals, exhibit several phenotypes in common, including ventricular remodeling, prolonged QT intervals, enhanced frequency of diastolic and/or systolic dysfunction, and decreased fractional shortening. High systemic lipid concentrations are thought to be the leading cause of lipid-related CVD in obese or diabetic individuals. However, an alternative possibility is that obesity leads to cardiac-specific steatosis, in which lipids and their metabolites accumulate within the myocardial cells themselves and thereby disrupt normal cardiovascular function. Drosophila has recently emerged as an excellent model to study the fundamental genetic mechanisms of metabolic control, as well as their relationship to heart function. Two recent studies of genetic and diet-induced cardiac lipotoxicity illustrate this. One study found that alterations in genes associated with membrane phospholipid metabolism may play a role in the abnormal lipid accumulation associated with cardiomyopathies. The second study showed that Drosophila fed a diet high in saturated fats, developed obesity, dysregulated insulin and glucose homeostasis, and severe cardiac dysfunction. Here, we review the current understanding of the mechanisms that contribute to the detrimental effects of dysregulated lipid metabolism on cardiovascular function. We also discuss how the Drosophila model could help elucidate the basic genetic mechanisms of lipotoxicity- and metabolic syndrome-related cardiomyopathies in mammals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.