Evidence map›Paper›PMID 21851156›Full record

ReviewBiochemistry and cell biology = Biochimie et biologie cellulaire2011

Cohesin: a critical chromatin organizer in mammalian gene regulation.

Richard Chien, Weihua Zeng, Alexander R Ball, Kyoko Yokomori

Abstract readReview
In one paragraph

Review in Biochemistry and cell biology = Biochimie et biologie cellulaire, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Regulation of chromatin organization during animal regeneration.Cell regeneration (London, England) · 2023
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Epigenetic regulation of EBV and KSHV latency.Current opinion in virology · 2013
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Richard ChienDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, California 92697-1700, USA.
Weihua Zeng
Alexander R Ball
Kyoko Yokomori
University of California, Irvine · US

Funding

Translational Research in Cancer Genomic MedicineT32CA113265 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LEE, WEN-HWA · 2007 to 2011
$1.4M
Epigenomic Analysis of Facioscapulohumeral Muscular DystrophyR01AR058548 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI YOKOMORI, KYOKO · 2009 to 2013
$1.3M
Role of Cohesin in Developmental Gene RegulationR21HD062951 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI YOKOMORI, KYOKO · 2010 to 2011
$413k
NCI NIH HHS T32 CA113265NCI NIH HHS T32-CA113265NIAMS NIH HHS AR058548NIAMS NIH HHS R01 AR058548NICHD NIH HHS HD062951NICHD NIH HHS R21 HD062951PHS HHS MDA4026
6 · The paper itself

Abstract

Cohesins are evolutionarily conserved essential multi-protein complexes that are important for higher-order chromatin organization. They play pivotal roles in the maintenance of genome integrity through mitotic chromosome regulation, DNA repair and replication, as well as gene regulation critical for proper development and cellular differentiation. In this review, we will discuss the multifaceted functions of mammalian cohesins and their apparent functional hierarchy in the cell, with particular focus on their actions in gene regulation and their relevance to human developmental disorders.

Indexed as

Gene Expression RegulationAbnormalities, MultipleAnimalsCell Cycle ProteinsChromatinChromatin Assembly and DisassemblyChromosomal Proteins, Non-HistoneCohesinsHumansCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesins

Identifiers

PMID21851156
PMCPMC4056987
OpenAlexW2052165934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.