ArticleLasers in medical science2012
Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues.
Article in Lasers in medical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- The clinical usefulness of optical coherence tomography during cancer interventions.Journal of cancer research and clinical oncology · 2018Pooled it
- Volumetric Imaging of Ex Vivo Oral Mucosa Specimens with Multi-Scale Wide Field-of-View Optical Coherence Tomography/Microscopy in Near-Infrared-II Window.Diagnostics (Basel, Switzerland) · 2026Article
- Deep-Learning-Based Automated Identification and Visualization of Oral Cancer in Optical Coherence Tomography Images.Biomedicines · 2023Article
- Use of Optical Coherence Tomography in Dentistry.International journal of dentistry · 2023Review
- Oral Cancer Screening by Artificial Intelligence-Oriented Interpretation of Optical Coherence Tomography Images.Radiology research and practice · 2022Review
- Optical coherence tomography's current clinical medical and dental applications: a review.F1000Research · 2021Review
- Identification of oral cancer in OCT images based on an optical attenuation model.Lasers in medical science · 2020Article
- Correlation between light absorbance and skin color using fabricated skin phantoms with different colors.Lasers in medical science · 2020Article
- Optical Radiomic Signatures Derived from Optical Coherence Tomography Images Improve Identification of Melanoma.Cancer research · 2019Article
- Human ex-vivo oral tissue imaging using spectral domain polarization sensitive optical coherence tomography.Lasers in medical science · 2017Article
- The Use of Optical Coherence Tomography in Dental Diagnostics: A State-of-the-Art Review.Journal of healthcare engineering · 2017Review
- Diffuse optical microscopy for quantification of depth-dependent epithelial backscattering in the cervix.Journal of biomedical optics · 2016Article
- Precancerous esophageal epithelia are associated with significantly increased scattering coefficients.Biomedical optics express · 2015Article
- Wide-field in vivo oral OCT imaging.Biomedical optics express · 2015Article
- In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe.Biomedical optics express · 2015Article
- Scattering coefficients of mice organs categorized pathologically by spectral domain optical coherence tomography.BioMed research international · 2014Article
- Quantitative diagnosis of colorectal polyps by spectral domain optical coherence tomography.BioMed research international · 2014Article
- Quantitative optical coherence tomography of fluid-filled oral mucosal lesions.Lasers in medical science · 2013Article
- Quantitative measurement of optical attenuation coefficients of cell lines CNE1, CNE2, and NP69 using optical coherence tomography.Lasers in medical science · 2013Article
- Quantitative analysis of rectal cancer by spectral domain optical coherence tomography.Physics in medicine and biology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selecting the most representative site for biopsy is crucial in establishing a definitive diagnosis of oral epithelial dysplasia. The current process involves clinical examination that can be subjective and prone to sampling errors. The aim of this study was therefore to investigate the use of optical coherence tomography (OCT) for differentiation of normal and dysplastic oral epithelial samples, with a view to developing an objective and reproducible approach for biopsy site selection. Biopsy samples from patients with fibro-epithelial polyps (n = 13), mild dysplasia (n = 2), and moderate/severe dysplasia (n = 4) were scanned at 5-μm intervals using an OCT microscope and subsequently processed and stained with hematoxylin and eosin (H&E). Epithelial differentiation was measured from the rate of change (gradient) of the backscattered light intensity in the OCT signal as a function of depth. This parameter is directly related to the density of optical scattering from the cell nuclei. OCT images of normal oral epithelium showed a clear delineation of the mucosal layers observed in the matching histology. However, OCT images of oral dysplasia did not clearly identify the individual mucosal layers because of the increased density of abnormal cell nuclei, which impeded light penetration. Quantitative analysis on 2D-OCT and histology images differentiated dysplasia from normal control samples. Similar analysis on 3D-OCT datasets resulted in the reclassification of biopsy samples into the normal/mild and moderate/severe groups. Quantitative differentiation of normal and dysplastic lesions using OCT offers a non-invasive objective approach for localizing the most representative site to biopsy, particularly in oral lesions with similar clinical features.
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